{"title":"[Increased proteolytic activity of cathepsin D in the skin of rats after administration of various anti-inflammatory drugs].","authors":"J A Pałka, Z Galewska, K Wróbel","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Cathepsin D activity and type I and III collagens content in the skin of rats treated with some antiinflammatory drugs (acetylsalicylic acid, phenylbutazone, indomethacin, colchicine and prednisone) were evaluated. It was found that investigated drugs evoke increased activity of cathepsin D and decreased collagen content (mainly type I) in this tissue. The correlation between type I collagen content and proteolytic activity was noticed.</p>","PeriodicalId":20732,"journal":{"name":"Przeglad dermatologiczny","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad dermatologiczny","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cathepsin D activity and type I and III collagens content in the skin of rats treated with some antiinflammatory drugs (acetylsalicylic acid, phenylbutazone, indomethacin, colchicine and prednisone) were evaluated. It was found that investigated drugs evoke increased activity of cathepsin D and decreased collagen content (mainly type I) in this tissue. The correlation between type I collagen content and proteolytic activity was noticed.
期刊介绍：
Przegląd Dermatologiczny (ang. Dermatological Review) is a bimonthly magazine of the Polish Dermatological Association. It publishes original (clinical and experimental) papers, review papers, care reports, reports from congresses, reviews of books, announcements, letters to the editor and special papers (requested by the editors), concerning selected dermatological and interdisciplinary issues. Papers sent to the editor are reviewed.
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