Medical and pharmaceutical application of oxidized cellulose

Branka Rodić - Grabovac, Pero Sailović, Nina Lipić
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Abstract

Cellulose is the most abundant natural polymer and versatile starting material for chemical modification for obtaining products with various applications. The oxidation of cellulose results in derivatives with improved properties, including the products with new, specific features that can be used for medical and pharmaceutical purposes. Due to its biocompatibility and biodegradibility, the oxidized cellulose (6-carboxycellulose) is widely used as a hemostatic agent, as a barrier for the prevention of postsurgical adhesion, in bandage products for covering different wounds, as an excipient in the production of tablets, various gels and pharmaceutical suspensions. In addition to these applications, the oxidized cellulose may be used for the production of surgical sutures, as a drug carrier in products with gradual/controlled release, and as a material in tissue engineering.
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氧化纤维素的医疗和制药应用
纤维素是最丰富的天然高分子材料,也是用途广泛的化学改性原料,可获得各种用途的产品。纤维素的氧化产生具有改进性能的衍生物,包括具有可用于医疗和制药目的的新的特定特征的产品。由于其生物相容性和生物降解性,氧化纤维素(6-羧基纤维素)被广泛用作止血剂,作为防止术后粘连的屏障,用于覆盖不同伤口的绷带产品,作为片剂、各种凝胶和药物混悬液的辅料。除了这些应用之外,氧化纤维素还可用于生产外科缝合线,作为逐渐/可控释放产品中的药物载体,以及作为组织工程中的材料。
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