A Markov Model Developed For Sodium Channel Currents In Cerebellar Purkinje Neurons

Abstract

In this study, a Markov model for gating kinetics of sodium channel currents in dissociated cerebellar Purkinje neurons is developed. The model is based on voltage-clamped, resurgent and action potential evoked currents, known as macroscopic currents. It is different from previously developed models. In this model, some modifications are made in the number of states and channel rate constants. The model parameters are determined using trial and error procedure to minimizing the error between model responses and three experimental data sets. The developed sodium channel model reproduces quantitatively all features of the experimental data sets, with minor discrepancies