Using computational models for development of the three-dimensional visualization in molecular biology

R. Muhamedyev, Y. Daineko, D. Bari, A. Mansharipova
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Abstract

A method for three-dimensional visualization of molecular biology processes modeled by chemical kinetic equations is presented. To implement this visualization, the software in C# and a database of three-dimensional forms that model molecular complexes are developed. The quantitative parameters in this visualization scheme are determined from kinetic equations governing the participating components, so our visualization is not only qualitative but also quantitative. As a case study, it was visualized a mathematical model for mitochondria-dependent apoptosis (programmed cell death) proposed by Bagci et all [19].
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利用计算模型发展分子生物学的三维可视化
提出了一种用化学动力学方程模拟分子生物学过程的三维可视化方法。为了实现这种可视化,开发了c#软件和一个三维形式的数据库来模拟分子复合物。该可视化方案中的定量参数由控制参与组分的动力学方程确定,因此我们的可视化不仅是定性的,而且是定量的。作为一个案例研究,Bagci等人[19]提出了线粒体依赖性凋亡(程序性细胞死亡)的数学模型。
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