Correlations of oxidized low density lipoprotein with insulin, leptin and risk of cardiovascular disease in a group of diabetic obese Tunisian women.

Abstract

At the obese diabetic ones, there’s a disturbance of lipid parameters from where the installation of an insulin resistance responsible for the development of non-insulin-dependent diabetes. Objectives: Our objectives were to evaluate the levels of insulin, leptin and oxidized LDL, and to search the link which could exist between these parameters and obesity represented by the body mass index (BMI >30 kg/m2). Methods: We proportioned the rate in total cholesterol, triglycerides, blood glucose, insulin, leptin, cholesterol LDL, cholesterol HDL and oxidized LDL at 53 obese women diabetic not carrying pathologies other than the diabetes type 2 and obesity compared to 21 witnesses who theirs are paired according to the age. Results: Our results shows that levels of total cholesterol, triglycerides, blood glucose, insulin, leptin, cholesterol LDL and oxidized LDL were higher in obese women with non-insulin-dependent diabetes mellitus compared with control group. Moreover a positive and significant correlation between body mass index and blood glucose (r=0.408, p=0.002), leptin (r=0.436, p=0.001), insulin (r=0.403, p=0.003), cholesterol LDL (r=0.365, p=0.007) and oxidized LDL (r=0.632, p<0.001) and a negative and significant correlation between body mass index and cholesterol HDL (r=-0.345, p=0.011) were observed. An analysis multivariate linear regression showed that leptin, cholesterol LDL and oxidized LDL were directly correlated with body mass index. Different biochemical parameters were correlated between each other and with body mass index. Leptin, cholesterol LDL and oxidized LDL were directly correlated to obesity. Body mass index is a strong predictor of leptin circulating levels, cholesterol LDL and oxidized LDL. Conclusion: Body mass index can predict leptin, cholesterol LDL and oxidized LDL circulating levels. So these parameters involved in diabetes mellitus and cardiovascular diseases can be controlling by regulation of body weight and prevention of obesity.