Understanding How the Relative Abundance of Candida Species Impacts Transcriptional Regulation in Co-culture Biofilms

Diksha Kool, Katy C. Kao, Wendy Lee
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Abstract

Candida albicans and Candida glabrata are common fungal species that can change from commensal to pathogen due to their ability to form robust biofilms. Candida species are the leading cause of life-threatening conditions like Candidemia, and the existing treatments for biofilm-related infections are suboptimal. Research shows that the relative abundance of the two Candida species promotes biofilm formation, enhances pathogenicity, and increases antibiotic resistance. Thus, focusing on the importance of co-culture, this paper utilizes RNA sequencing to investigate the gene expression leading to biofilm development in co-culture through a time-series study.
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了解念珠菌物种的相对丰度如何影响共培养生物膜的转录调控
白色念珠菌和光念珠菌是常见的真菌种类,由于它们能够形成坚固的生物膜,因此可以从共生转变为病原体。念珠菌是念珠菌病等危及生命的疾病的主要原因,而现有的生物膜相关感染治疗方法并不理想。研究表明,这两种念珠菌的相对丰度促进了生物膜的形成,增强了致病性,并增加了抗生素耐药性。因此,本文针对共培养的重要性,利用RNA测序技术,通过时间序列研究共培养中导致生物膜发育的基因表达。
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