Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases

F. Cobo, Clara Chamorro, F. Ramos, A. Concha
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Abstract

We report two cases of extranodal NK/T-cell lymphoma, nasal type, in immunocompetent patients without nasal cavity involvement. In the two cases, the initial presumptive diagnosis was tuberculosis and there was a rapid dissemination of the tumor with short survival after the hospital admittance. An autopsy was performed showing infiltration in several organs including lymph nodes and mesenteric and retroperitoneal fat. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype was CD45
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结外NK/ t细胞淋巴瘤不累及鼻腔与爱泼斯坦-巴尔病毒:多模态诊断为基础的两例
我们报告两例结外NK/ t细胞淋巴瘤,鼻型,在免疫功能正常的患者没有鼻腔的侵犯。在这两个病例中,最初的推定诊断是结核病,住院后肿瘤传播迅速,生存时间短。尸检显示几个器官浸润,包括淋巴结、肠系膜和腹膜后脂肪。组织切片显示血管中心和血管破坏生长模式,免疫表型为CD45
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