Effects of Exogenous Erythropoietin on Rabbit (Oryctolagus cuniculus) Hematological and Biochemical Parameters.

Comparative medicine Pub Date : 2023-12-01 Epub Date: 2023-11-15 DOI:10.30802/AALAS-CM-22-000107
Jessica K Levine, Josilene Nascimento Seixas, Jana M Ritter, Amanda Y Liew, Cassandra M Tansey
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Abstract

Rabbits can develop anemia due to serial phlebotomy or secondary to induced disease states. This study evaluated the effects of a single injection and three consecutive injections of erythropoietin in rabbits at 150 IU/kg and 1,000 IU/kg in order to determine whether these dosages produce a sustained increase in hematocrit. Analysis of CBC and chemistry parameters showed significant elevation in hematocrit one week after administration of 1,000 IU/kg erythropoietin for three consecutive days. These results indicate that this dosage regimen can increase hematocrit in apparently healthy, nonanemic rabbits for one week.

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外源性促红细胞生成素对兔血液学和生化指标的影响
兔可因连续放血或继发于诱导疾病状态而发生贫血。本研究评估了单次注射和三次连续注射促红细胞生成素(150 IU/kg和1000 IU/kg)对家兔的影响,以确定这些剂量是否会产生持续的红细胞压积增加。CBC和化学参数分析显示,连续3天给予1,000 IU/kg促红细胞生成素一周后,红细胞压积显著升高。这些结果表明,该给药方案可以增加红细胞压积在明显健康,无贫血家兔一周。
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