{"title":"Urinary thromboxane B2 and 2,3-dinor-thromboxane B2 in the neonate born at full-term age.","authors":"C Van Geet, J Arnout, E Eggermont, J Vermylen","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We have developed a method for measurement of urinary 2,3-dinor-TXB2, which is a reflection of the actual rate of TXA2 synthesis by platelets in vivo. This determination was based on purification by high-pressure liquid chromatography and on measurement by RIA. After validation of the assay, we established the range of urinary Tx metabolites in healthy infants born at full-term during their first week of life. The 2,3-dinor-TXB2 levels were higher than in adults and declined gradually during the first seven days of life.</p>","PeriodicalId":11520,"journal":{"name":"Eicosanoids","volume":"3 1","pages":"39-43"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eicosanoids","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We have developed a method for measurement of urinary 2,3-dinor-TXB2, which is a reflection of the actual rate of TXA2 synthesis by platelets in vivo. This determination was based on purification by high-pressure liquid chromatography and on measurement by RIA. After validation of the assay, we established the range of urinary Tx metabolites in healthy infants born at full-term during their first week of life. The 2,3-dinor-TXB2 levels were higher than in adults and declined gradually during the first seven days of life.
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