Effect of Sr2+ on 3D gel-printed Sr3−xMgx(PO4)2 composite scaffolds for bone tissue engineering

IF 5.6 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY International Journal of Minerals, Metallurgy, and Materials Pub Date : 2023-11-15 DOI:10.1007/s12613-023-2638-1

Hongyuan Liu, Jialei Wu, Siqi Wang, Jing Duan, Huiping Shao

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Abstract

Porous magnesium strontium phosphate (Sr_3−xMg_x(PO₄)₂) (x = 2, 2.5, 3) composite scaffolds were successfully prepared by three dimension gel-printing (3DGP) method in this study. The results show that Sr_0.5Mg_2.5(PO₄)₂ scaffolds had good compressive strength, and Sr_1.0Mg_2.0(PO₄)₂ scaffolds had good degradation rate in vitro. The weight loss rate of Sr_1.0Mg_2.0(PO₄)₂ scaffolds soaked in simulated body fluid (SBF) or 6 weeks was 6.96%, and pH value varied between 7.50 and 8.61, which was within the acceptable range of human body. Preliminary biological experiment shows that MC3T3-E1 cells had good adhesion and proliferation on the surface of Sr_3−xMg_x(PO₄)₂ scaffolds. Compared with pure Mg₃(PO₄)₂ scaffolds, strontium doped scaffolds had excellent comprehensive properties, which explain that Sr_3−xMg_x(PO₄)₂ composite scaffolds can be used for bone tissue engineering.

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Sr2+对3D凝胶打印Sr3−xMgx(PO4)2复合材料骨组织工程支架的影响

本研究采用三维凝胶打印(3DGP)方法成功制备了多孔磷酸镁锶(Sr3−xMgx(PO4)2) (x = 2,2.5, 3)复合支架。结果表明，Sr0.5Mg2.5(PO4)2支架具有良好的抗压强度，Sr1.0Mg2.0(PO4)2支架具有良好的体外降解率。Sr1.0Mg2.0(PO4)2支架在模拟体液(SBF)中浸泡6周后失重率为6.96%，pH值在7.50 ~ 8.61之间变化，在人体可接受范围内。初步生物学实验表明，MC3T3-E1细胞在Sr3−xMgx(PO4)2支架表面具有良好的粘附和增殖能力。与纯Mg3(PO4)2支架相比，锶掺杂支架具有优异的综合性能，这说明Sr3−xMgx(PO4)2复合支架可用于骨组织工程。

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来源期刊

International Journal of Minerals, Metallurgy, and Materials 工程技术-材料科学：综合

CiteScore

9.30

自引率

16.70%

发文量

205

审稿时长

2 months

期刊介绍： International Journal of Minerals, Metallurgy and Materials (Formerly known as Journal of University of Science and Technology Beijing, Mineral, Metallurgy, Material) provides an international medium for the publication of theoretical and experimental studies related to the fields of Minerals, Metallurgy and Materials. Papers dealing with minerals processing, mining, mine safety, environmental pollution and protection of mines, process metallurgy, metallurgical physical chemistry, structure and physical properties of materials, corrosion and resistance of materials, are viewed as suitable for publication.