{"title":"Dynamical analysis of an age-space structured malaria epidemic model","authors":"Jinliang Wang, Meiyu Cao, Toshikazu Kuniya","doi":"10.1007/s00033-023-02097-4","DOIUrl":null,"url":null,"abstract":"Abstract In this paper, we will revisit the model studied in Lou and Zhao (J Math Biol 62:543–568, 2011), where the model takes the form of a nonlocal and time-delayed reaction–diffusion model arising from the fixed incubation period. We consider the infection age to be a continuous variable but without the limitation of the fixed incubation period, leading to an age-space structured malaria model in a bounded domain. By performing the elementary analysis, we investigate the well-posedness of the model by proving the global existence of the solution, define the explicit formula of basic reproduction number when all parameters remain constant. By analyzing the characteristic equations and designing suitable Lyapunov functions, we also establish the threshold dynamics of the constant disease-free and positive equilibria. Our theoretical results are also validated by numerical simulations for 1-dimensional and 2-dimensional domains.","PeriodicalId":54401,"journal":{"name":"Zeitschrift fur Angewandte Mathematik und Physik","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Angewandte Mathematik und Physik","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00033-023-02097-4","RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATHEMATICS, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Abstract In this paper, we will revisit the model studied in Lou and Zhao (J Math Biol 62:543–568, 2011), where the model takes the form of a nonlocal and time-delayed reaction–diffusion model arising from the fixed incubation period. We consider the infection age to be a continuous variable but without the limitation of the fixed incubation period, leading to an age-space structured malaria model in a bounded domain. By performing the elementary analysis, we investigate the well-posedness of the model by proving the global existence of the solution, define the explicit formula of basic reproduction number when all parameters remain constant. By analyzing the characteristic equations and designing suitable Lyapunov functions, we also establish the threshold dynamics of the constant disease-free and positive equilibria. Our theoretical results are also validated by numerical simulations for 1-dimensional and 2-dimensional domains.
期刊介绍：
The Journal of Applied Mathematics and Physics (ZAMP) publishes papers of high scientific quality in Fluid Mechanics, Mechanics of Solids and Differential Equations/Applied Mathematics. A paper will be considered for publication if at least one of the following conditions is fulfilled:
The paper includes results or discussions which can be considered original and highly interesting.
The paper presents a new method.
The author reviews a problem or a class of problems with such profound insight that further research is encouraged.
The readers of ZAMP will find not only articles in their own special field but also original work in neighbouring domains. This will lead to an exchange of ideas; concepts and methods which have proven to be successful in one field may well be useful to other areas. ZAMP attempts to publish articles reasonably quickly. Longer papers are published in the section "Original Papers", shorter ones may appear under "Brief Reports" where publication is particularly rapid. The journal includes a "Book Review" section and provides information on activities (such as upcoming symposia, meetings or special courses) which are of interest to its readers.
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