Diagnosis of choroid plexus papilloma: Current perspectives and future directions

Esma'il Akade , Fereshteh Aslani , Kimia Verdi , Mohammad Bahadoram , Gholam Abbas Kaydani
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Abstract

Choroid plexus papilloma (CPP) is a rare, slow-growing, and typically benign brain tumor that predominantly affects children. CPP is characterized by well-defined circular or lobulated masses in the ventricles, leading to symptoms related to increased intracranial pressure and hydrocephalus. CPP diagnosis relies on a combination of clinical presentation, imaging findings, and histological examination. The World Health Organization (WHO) classification categorizes choroid plexus tumors into CPP (Grade І), atypical CPP (aCPP, Grade II), and choroid plexus carcinoma (CPC, Grade III). This article reviewed current diagnostics modalities and explored the emergence of new diagnostic methods for CPP. Research on molecular markers and genetic alterations associated with CPP is ongoing, and some potential markers have been identified. These results offered insights into potential therapeutic targets and personalized treatment approaches for CPP. Advancements in radiomics and liquid biopsy hold promise for improving diagnostic accuracy and monitoring treatment outcomes for choroid plexus tumors. Radiomics can provide quantitative data from imaging studies, whereas liquid biopsy can analyze tumor-derived genetic material and molecular markers from body fluids, such as cerebrospinal fluid (CSF) and blood. The rapidly evolving fields of molecular and genetic research and novel diagnostic methods require continuous updates and advancements before their application in clinical practice. We hope that these advancements will lead to earlier and more precise diagnoses, better treatment options, and improved outcomes in patients with CPP and other brain tumors.

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脉络丛乳头状瘤的诊断:当前视角和未来方向
脉络丛乳头状瘤(CPP)是一种罕见、生长缓慢、典型的良性脑肿瘤,主要影响儿童。脉络丛乳头状瘤的特点是脑室内有界限清楚的圆形或分叶肿块,导致与颅内压增高和脑积水有关的症状。CPP 的诊断需要结合临床表现、影像学检查结果和组织学检查。世界卫生组织(WHO)将脉络丛肿瘤分为CPP(І级)、非典型CPP(aCPP,Ⅱ级)和脉络丛癌(CPC,Ⅲ级)。本文回顾了目前的诊断方法,并探讨了新出现的 CPP 诊断方法。与 CPP 相关的分子标记和基因改变的研究正在进行中,并已确定了一些潜在标记。这些研究成果为 CPP 的潜在治疗目标和个性化治疗方法提供了启示。放射组学和液体活检技术的进步为提高脉络丛肿瘤的诊断准确性和监测治疗效果带来了希望。放射组学可提供成像研究的定量数据,而液体活检可分析肿瘤衍生的遗传物质以及脑脊液(CSF)和血液等体液中的分子标记物。分子和基因研究领域以及新型诊断方法发展迅速,在应用于临床实践之前需要不断更新和进步。我们希望这些进步能为 CPP 和其他脑肿瘤患者带来更早更精确的诊断、更好的治疗方案和更好的治疗效果。
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来源期刊
Cancer pathogenesis and therapy
Cancer pathogenesis and therapy Surgery, Radiology and Imaging, Cancer Research, Oncology
CiteScore
0.80
自引率
0.00%
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0
审稿时长
54 days
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Table of Contents Cover Corrigendum to “Gene mutations in newly diagnosed multiple myeloma patients detected by next-generation sequencing technology” [Cancer Pathog Ther. 2024;2:205–211] Table of Contents Current and future perspectives on the regulation and functions of miR-545 in cancer development
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