{"title":"Butadiene sulfone-catalyzed monobromination of arenes with NBS as the bromination source: A simple, mild, efficient, and chemoselective protocol","authors":"Amit Sharma, Santosh Rudrawar, Hemant R. Jadhav","doi":"10.2174/1570178620666230914164247","DOIUrl":null,"url":null,"abstract":"Introduction: In literature, dimethyl sulfoxide (DMSO) catalyzed bromination of arenes and heteroarenes is reported. Method: In this study, simple, mild, and chemoselective N-bromosuccinimide (NBS) mediated monobromination of arenes and heteroarenes using butadiene sulfone as a catalyst is reported. Result: Butadiene sulfone is a good substitute for DMSO as it is volatile, easy to recover and recycle, and environment-friendly. Conclusion: The method has been demonstrated to give high-yield brominated products for an extensive range of activated and deactivated arenes.","PeriodicalId":18116,"journal":{"name":"Letters in Organic Chemistry","volume":"25 1","pages":"0"},"PeriodicalIF":0.7000,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Letters in Organic Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1570178620666230914164247","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: In literature, dimethyl sulfoxide (DMSO) catalyzed bromination of arenes and heteroarenes is reported. Method: In this study, simple, mild, and chemoselective N-bromosuccinimide (NBS) mediated monobromination of arenes and heteroarenes using butadiene sulfone as a catalyst is reported. Result: Butadiene sulfone is a good substitute for DMSO as it is volatile, easy to recover and recycle, and environment-friendly. Conclusion: The method has been demonstrated to give high-yield brominated products for an extensive range of activated and deactivated arenes.
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Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
The journal is an essential reading for all organic chemists belonging to both academia and industry.
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