Antihypertensive Effect of Milk Fermented by Lactiplantibacillus plantarum K79 on Spontaneously Hypertensive Rats

Abstract

The aim of this study is to investigate whether milk fermented by Lactiplantibacillus plantarum K79, which exhibits ACE inhibitory activity, has an effect on lowering the blood pressure of hypertensive rats and to investigate biomarker changes in their blood. Experimental group: normal group (NG, WKY): distilled water, control group (NCG, SHR): distilled water, high treatment group (HTG, SHR): 500 mg/kg/day, medium treatment group (MTG, SHR): 335 mg/kg/day, low treatment group (LTG, SHR): 170 mg/kg/day, positive control group(PCG, SHR): Enalapril, 10 mg/kg/day. The experimental animals used in this study were divided into groups composed of 8 animals. In terms of weight change, a significant difference was observed between the normal group and the SHR group, but there was no significant difference between the SHR group. After 8 weeks of feeding, Blood pressure was lowered more significantly in the HTG(209.9±13.3 mmHg) than in the NCG(230.8±7.3 mmHg). The treatment group has an effect of lowering blood pressure by significantly suppressing blood pressure-related biomarker protein expression than NG. The results obtained can be used as an antihypertensive material in a variety of food raw materials.