The Role of Substance P and NK1 Receptors in Mild to Severe Traumatic Brain Injury: From CTE to ICP

Robert Vink, Frances Corrigan
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Abstract

Binding of substance P to the tachykinin NK1 receptor is involved in numerous physiological and pathophysiological processes ranging from modulation of sensory and motor function to inflammation, cancer, and brain injury, amongst others. NK1 antagonists therefore have enormous potential as a therapeutic intervention in a wide variety of human disease states, albeit that the clinical potential is yet to be fully realised. In the current review, the role of substance P in the pathophysiology of traumatic brain injury (TBI) will be discussed, summarising both experimental and clinical observations in mild, moderate, and severe TBI. In addition, the potential for NK1 antagonists to be a valuable therapeutic intervention against chronic traumatic encephalopathy (CTE) after repeated concussive brain injury as well as raised intracranial pressure (ICP) following severe TBI will be addressed, highlighting the various pathophysiological processes that are attenuated by the intervention.
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P物质和NK1受体在轻至重度颅脑外伤中的作用:从CTE到ICP
P物质与速激肽NK1受体的结合涉及许多生理和病理生理过程,从感觉和运动功能的调节到炎症、癌症和脑损伤等。因此,尽管临床潜力尚未完全实现,但NK1拮抗剂作为各种人类疾病状态的治疗干预具有巨大的潜力。本文将讨论P物质在创伤性脑损伤(TBI)病理生理中的作用,总结轻度、中度和重度TBI的实验和临床观察结果。此外,将讨论NK1拮抗剂作为反复脑震荡后慢性创伤性脑病(CTE)以及严重TBI后颅内压升高(ICP)的有价值的治疗干预的潜力,强调通过干预减弱的各种病理生理过程。
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