Dietary vanillic acid prevents postmenopausal symptoms in ovariectomized mice

IF 0.7 4区 农林科学 Q4 FOOD SCIENCE & TECHNOLOGY Food Science and Technology Research Pub Date : 2023-01-01 DOI:10.3136/fstr.fstr-d-23-00139
Teruyoshi Tanaka, Rui Hironaka, Takashi Fukuda, Masashi Ando, Norifumi Shirasaka, Yoshimi Homma
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Abstract

Postmenopausal women have an increased risk of developing metabolic diseases, such as osteoporosis, obesity, and diabetes. Thus, chemoprophylaxis for postmenopausal symptoms through the daily diet is critical. Vanillic acid (VA) is a phenolic compound found in the herbal medicine “Toki” (Angelica acutiloba) and the mycelium of the shiitake mushroom Lentinula edodes. VA has no affinity for estrogen receptors and may offer preventive effects against these diseases. Here, we demonstrate the metabolic effects of VA in ovariectomized mice. Ten-week-old ovariectomized mice were fed a VA-containing diet (100 mg/kg body weight/day) for 10 weeks. Dietary VA significantly prevented femoral bone mineral density loss and also reduced the increases in glucose levels and white adipose tissue weights compared with those in the control group. Furthermore, uterine enlargement was not observed because of these beneficial effects. Our findings suggest that VA has the potential to mitigate postmenopausal symptoms in ovariectomized mice without estrogenic action.
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食用香草酸可预防去卵巢小鼠的绝经后症状
绝经后妇女患代谢性疾病的风险增加,如骨质疏松症、肥胖症和糖尿病。因此,通过日常饮食对绝经后症状进行化学预防是至关重要的。香草酸(VA)是一种酚类化合物,存在于草药“Toki”(当归)和香菇香菇的菌丝中。VA对雌激素受体没有亲和力,可能对这些疾病有预防作用。在这里,我们展示了VA在去卵巢小鼠中的代谢作用。10周龄去卵巢小鼠饲喂含va的日粮(100 mg/kg体重/天)10周。与对照组相比,膳食VA显著防止了股骨骨密度损失,也降低了葡萄糖水平和白色脂肪组织重量的增加。此外,由于这些有益的作用,没有观察到子宫扩大。我们的研究结果表明,在没有雌激素作用的情况下,VA有可能减轻卵巢切除小鼠的绝经后症状。
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来源期刊
Food Science and Technology Research
Food Science and Technology Research 工程技术-食品科技
CiteScore
1.40
自引率
0.00%
发文量
53
审稿时长
1.9 months
期刊介绍: ''Food Science and Technology Research'', published by the Japanese Society for Food Science and Technology, features reviews as well as original and technical articles on basic and applied food research.
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