{"title":"基于高分辨光声显微成像的肝癌微血管特征分析","authors":"孙彤 Sun Tong, 黄国家 Huang Guojia, 张振辉 Zhang Zhenhui","doi":"10.3788/cjl230615","DOIUrl":null,"url":null,"abstract":"建立了小鼠原位肝癌模型,利用活体荧光成像系统激发的荧光信号对肿瘤进行了定位,通过光声显微成像系统观察了正常肝小叶、肿瘤中心和癌旁的微血管结构特征和血氧功能。结果表明,正常的血管分布均匀、分化良好,而肿瘤的血管分布不均匀且混乱,分支直径增加,更适合低氧环境。光声技术在研究肝细胞癌方面展现出巨大的潜力,可以为肿瘤抗血管生成治疗和诸多肝脏相关疾病的诊断提供更深入的见解。","PeriodicalId":47922,"journal":{"name":"CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG","volume":"29 7 1","pages":"0"},"PeriodicalIF":1.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3788/cjl230615","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPTICS","Score":null,"Total":0}
引用次数: 0
基于高分辨光声显微成像的肝癌微血管特征分析
建立了小鼠原位肝癌模型,利用活体荧光成像系统激发的荧光信号对肿瘤进行了定位,通过光声显微成像系统观察了正常肝小叶、肿瘤中心和癌旁的微血管结构特征和血氧功能。结果表明,正常的血管分布均匀、分化良好,而肿瘤的血管分布不均匀且混乱,分支直径增加,更适合低氧环境。光声技术在研究肝细胞癌方面展现出巨大的潜力,可以为肿瘤抗血管生成治疗和诸多肝脏相关疾病的诊断提供更深入的见解。
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