Characteristics of infants requiring mechanical reventilation in those previously ventilated during the neonatal period

WV Nongaya, P Jeena
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Abstract

Background. Factors predisposing ventilated neonates to the risk for reventilation during infancy are largely unknown.Objective. To identify factors that predispose previously mechanically ventilated neonates to reventilation.Methods. Mechanically ventilated infants at the Inkosi Albert Luthuli Central Hospital paedicatric intensive care unit (PICU), SouthAfrica, who were also ventilated during the neonatal period were compared with age-, gender-, timing-, and site-matched controls whowere not reventilated during infancy. Neonatal and postnatal records of the two cohorts and data on their clinical presentation andoutcomes of the ICU admission were collected and analysed using descriptive and comparative statistics.Results. Thirty-one reventilated index cases were identified at the PICU over a 15-month period and were matched with 31non-reventilated controls. Ex-preterm babies (n=26; 84%), males (n=19; 61.3%), chronic lung disease (CLD) of infancy (n=5; 16.7%)and prolonged neonatal length of stay (LOS) were common neonatal factors in reventilated neonates. Pneumonia (n=22; 71%), sepsis(n=11; 35.5%) and upper airway obstruction (UAO) (n=8; 25.8%) were common reasons for reventilation in neonates. There were noHIV-positive cases. Of the 31 reventilated cases, 5 (16.1%) demised and 15 (57.6%) survivors had morbidities, commonly seizures (n=8;30.8%) and short bowel syndrome (n=3; 11.5%).Conclusion. Pre-term birth, male, CLD of infancy and prolonged LOS were associated with an increased risk for mechanical reventilationin infancy. Pneumonia, sepsis, CLD of infancy and UAO were common indications for reventilation post neonatal ICU discharge.
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新生儿期需要机械通气的婴儿的特征
背景。导致通气新生儿在婴儿期发生通气风险的因素在很大程度上是未知的。目的:探讨早期机械通气新生儿易发生通气的因素。在南非Inkosi Albert Luthuli中心医院儿科重症监护病房(PICU)进行机械通气的婴儿,在新生儿期也进行了通气,并与年龄、性别、时间和地点匹配的婴儿期未进行通气的对照组进行了比较。收集两组患者的新生儿和产后记录,以及他们的临床表现和ICU入院结果的数据,并使用描述性和比较统计学进行分析。15个月期间在PICU发现31例呼吸恢复指数病例,并与31例未呼吸恢复的对照组相匹配。早产儿(n=26;84%),男性(n=19;61.3%),婴儿期慢性肺病(CLD) (n=5;16.7%)和延长新生儿住院时间(LOS)是呼吸恢复新生儿常见的新生儿因素。肺炎(n = 22;71%),脓毒症(n = 11;35.5%)和上气道阻塞(UAO) (n=8;25.8%)是新生儿呼吸的常见原因。无hiv阳性病例。在31例恢复通气的病例中,5例(16.1%)死亡,15例(57.6%)幸存者有发病,常见的是癫痫发作(n=8;30.8%)和短肠综合征(n=3;11.5%) .Conclusion。早产、男性、婴儿CLD和长时间LOS与婴儿机械通气风险增加有关。肺炎、败血症、婴儿期CLD和UAO是新生儿ICU出院后通气的常见指征。
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来源期刊
CiteScore
0.60
自引率
0.00%
发文量
21
审稿时长
12 weeks
期刊最新文献
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