Hyponatremia: A Marker of Inflammation for COVID-19

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Journal of Laboratory Physicians Pub Date : 2023-09-18 DOI:10.1055/s-0043-1773808
Jesús Salvador Sánchez-Díaz, Karla Gabriela Peniche-Moguel
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Abstract

We have read with great interest the article by Nair et al[1] in which they explain the presence of two subphenotypes of acute respiratory distress syndrome (ARDS) secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through serum markers of systemic inflammation such as ferritin (ferritin), serum lactate dehydrogenase (LDH) and C-reactive protein (CRP), which are associated with worse results in terms of days of stay in the intensive care unit (ICU), days of mechanical ventilation, and higher mortality; interleukin-6 (IL-6) is the proinflammatory cytokine involved in the cascade of systemic damage. Therefore we share our experience and research on the other side of the world: under the premise that elevated serum levels of IL-6[2] favor non-osmotic secretion of antidiuretic hormone (ADH) with the consequent presence of hyponatremia this electrolyte disturbance could be another marker of severity and poor prognosis; therefore, SARS-CoV-2 would be the etiological agent in which the IL-6 released is recognized as the main inflammatory mediator of the acute phase with hematological, immunological, endocrinological, and metabolic effects.[3]
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低钠血症:COVID-19炎症的标志
我们饶有兴趣地阅读了Nair等人[1]的文章,他们通过全身炎症的血清标志物,如铁蛋白(铁蛋白)、血清乳酸脱氢酶(LDH)和c反应蛋白(CRP),解释了严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)继发于急性呼吸窘迫综合征(ARDS)的两种亚表型的存在,这两种亚表型与重症监护室(ICU)住院天数的恶化有关。机械通气天数,死亡率更高;白细胞介素-6 (IL-6)是参与系统性损伤级联反应的促炎细胞因子。因此,我们在世界的另一端分享我们的经验和研究:在血清IL-6水平升高[2]有利于抗利尿激素(ADH)的非渗透性分泌并随之出现低钠血症的前提下,这种电解质紊乱可能是严重程度和预后不良的另一个标志;因此,SARS-CoV-2可能是病原,其中释放的IL-6被认为是急性期的主要炎症介质,具有血液学、免疫学、内分泌学和代谢作用。[3]
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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
自引率
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发文量
99
审稿时长
31 weeks
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