RISK EVALUATION OF THROMBO-EMBOLISM DURING STROKE IN ASIAN PATIENTS: NEED FOR PHARMACOLOGICAL THROMBOPROPHYLAXIS

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Abstract

Venous thrombo-embolism (VTE) is one of the serious complications in stroke patients. Early diagnosis and proper treatment are warranted to mitigate morbidity and mortality. Epidemiological evidence available so far favours much lower risk of VTE among Asians. Pharmacological management against VTE is highly effective but it is expensive and increases the chances of bleeding. Can the antithrombotic treatment be recommended as a prophylaxis against VTE among Asian population or we have cheaper, effective, and safer options available? Nonpharmacological treatment to prevent the incidence of VTE include graduated compression stockings, intermittent pneumatic compressions and early mobilization. Putting these options into action without pharmacological treatment may prove sufficient and effective without risking the patients to suffer from bleeding complications, particularly in cases where the severity of illness and chances of VTE are low. In such cases, non-pharmacological prophylaxis may prove more cost effective. This will improve the quality of care in regions where most of the healthcare expenses are managed through out-of-pocket spending.
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亚洲患者中风期间血栓栓塞的风险评估:需要药物血栓预防
静脉血栓栓塞是脑卒中患者的严重并发症之一。为了降低发病率和死亡率,早期诊断和适当治疗是必要的。目前可获得的流行病学证据表明,亚洲人患静脉血栓栓塞的风险要低得多。静脉血栓栓塞的药物治疗是非常有效的,但它是昂贵的,并增加出血的机会。抗血栓治疗是否可以在亚洲人群中推荐作为静脉血栓栓塞的预防手段,或者我们有更便宜、更有效、更安全的选择?预防静脉血栓栓塞发生的非药物治疗包括渐进式压缩长袜、间歇性气动压缩和早期活动。在没有药物治疗的情况下,将这些选择付诸行动可能证明是充分和有效的,而不会给患者带来出血并发症的风险,特别是在疾病严重程度和静脉血栓栓塞几率较低的情况下。在这种情况下,非药物预防可能证明更具成本效益。这将提高大部分医疗费用通过自费支付管理的区域的医疗质量。
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