{"title":"Application of a novel Revolver apparatus for a biorelevant dissolution test of ropinirole sustained release tablets","authors":"Bartłomiej Milanowski, Mateusz Kuprianowicz","doi":"10.33320/maced.pharm.bull.2023.69.03.118","DOIUrl":null,"url":null,"abstract":"Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).","PeriodicalId":30550,"journal":{"name":"Makedonsko Farmacevtski Bilten","volume":"40 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Makedonsko Farmacevtski Bilten","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33320/maced.pharm.bull.2023.69.03.118","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo predictions (IVIVP). A recently developed Revolver apparatus (Fig. 1) allows mimicking the acceptor fluid composition and flow as well as pH changes occurring in the human fasted intestine. This work presents and showcases the first application of the Revolver in dissolution testing of SR tablets with ropinirole hydrochloride (RH).
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