A case of hemolytic disease of the newborn caused by anti-Hro and anti-e.

Abstract

A Chinese woman of blood group B, D- and her husband of blood group AB, CCDee were examined. The woman had not been transfused before. Their first two babies died. Anti-Hro and anti-e were found in the mother's serum. During her third pregnancy, the titer of antibodies went up quickly, approximately one titer per month. After 36 weeks of pregnancy, the baby was delivered by Caesarean section. The cord blood Hb was 88 g/L, his red blood cell count 2.7 x 10(12)/L, and total bilirubin 114.6 mol/L. The baby was of blood group AB, and CDe-D-genotype. Exchange transfusion was begun 2.5 hours after birth. O, ccDEE washed red cells together with group AB plasma were used. Two days later, 70 ml washed O, ccDEE concentrated red cells were administered. The baby is alive and in good health.