Is the reduction of VIP the clue to the pathophysiology of Hirschsprung's disease?

Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood Pub Date : 1990-06-01 DOI:10.1055/s-2008-1042574

L T Larsson, F Sundler

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引用次数: 6

Abstract

The reduction of vasoactive intestinal peptide-(VIP) containing nerve fibres in the aganglionic segment in Hirschsprung's disease is thought to contribute to the sustained contraction of this intestinal segment. In order to study the significance of VIP in the pathogenesis of Hirschsprung's disease we used immunohistochemistry to evaluate the reduction of VIP-immunoreactive nerve fibres in aganglionic intestine compared to the ganglionic one. The VIP nerve fiber density was compared with the type of onset of disease (e.g. neonatal ileus or obstipation) and with the length of the aganglionic segment. No statistically significant correlation between these factors could be registered. This indicates a high complexity of the neuronal derangement in aganglionic intestine and that the degree of VIP deficiency alone does not correlate with the severity of the disease.

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VIP的减少是先天性巨结肠病病理生理学的线索吗?

巨结肠病神经节段含有血管活性肠肽(VIP)的神经纤维的减少被认为是导致该肠段持续收缩的原因。为了研究VIP在Hirschsprung病发病机制中的意义，我们采用免疫组织化学方法评价了神经节肠与神经节肠相比VIP免疫反应性神经纤维的减少。VIP神经纤维密度与疾病发病类型(如新生儿肠梗阻或梗阻)和神经节段长度进行比较。这些因素之间没有统计学上显著的相关性。这表明神经节肠中神经元紊乱的高度复杂性，VIP缺乏的程度单独与疾病的严重程度无关。

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Zeitschrift fur Kinderchirurgie : organ der Deutschen, der Schweizerischen und der Osterreichischen Gesellschaft fur Kinderchirurgie = Surgery in infancy and childhood

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