Observations on the reproductive biology of Onchocerca volvulus.

Acta Leidensia Pub Date : 1990-01-01
H Schulz-Key
{"title":"Observations on the reproductive biology of Onchocerca volvulus.","authors":"H Schulz-Key","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>This study compiles observations on the reproductive capacity of O. volvulus. Adult parasites enzymatically isolated from excised onchocercomata of untreated and chemotherapeutically treated patients, and from inhabitants living in areas with long vector control, were investigated to assess their fecundity. Changes of microfilaria development in utero and microfilaria release were assessed or estimated after treatment of patients with micro-filaricidal drugs that interfered with the development of intra-uterine stages. Intra-uterine production of microfilariae: After treatment of patients with ivermectin a daily development of 2500 to 4000 uterine microfilariae per female worm was observed. Actual output of microfilariae: Microfilariae left actively the female worms. The daily microfilaria release in vivo was 700 to 900 microfilariae, assessed after treatment of patients with mebendazole. In vitro most worms isolated from untreated patients shed between 500 to 1500 microfilariae per day.-The microfilarial load of 56 adult patients calculated from microfilarial skin counts was 12 million on the average. Taken for granted a mean life span of a microfilaria of 1.0 to 1.5 years, 22 to 47 female worms per patient would suffice to maintain this microfilarial load on a constant level. Excision of all palpable nodules showed a geometric mean of 15.9 female worms in these patients. It is suggested that factors intrinsic in the host and the adult worms partially operate together to regulate and maintain a stable microfilarial density.</p>","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"59 1-2","pages":"27-44"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Leidensia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

This study compiles observations on the reproductive capacity of O. volvulus. Adult parasites enzymatically isolated from excised onchocercomata of untreated and chemotherapeutically treated patients, and from inhabitants living in areas with long vector control, were investigated to assess their fecundity. Changes of microfilaria development in utero and microfilaria release were assessed or estimated after treatment of patients with micro-filaricidal drugs that interfered with the development of intra-uterine stages. Intra-uterine production of microfilariae: After treatment of patients with ivermectin a daily development of 2500 to 4000 uterine microfilariae per female worm was observed. Actual output of microfilariae: Microfilariae left actively the female worms. The daily microfilaria release in vivo was 700 to 900 microfilariae, assessed after treatment of patients with mebendazole. In vitro most worms isolated from untreated patients shed between 500 to 1500 microfilariae per day.-The microfilarial load of 56 adult patients calculated from microfilarial skin counts was 12 million on the average. Taken for granted a mean life span of a microfilaria of 1.0 to 1.5 years, 22 to 47 female worms per patient would suffice to maintain this microfilarial load on a constant level. Excision of all palpable nodules showed a geometric mean of 15.9 female worms in these patients. It is suggested that factors intrinsic in the host and the adult worms partially operate together to regulate and maintain a stable microfilarial density.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
盘尾丝虫生殖生物学的观察。
本研究汇编了对O. volvulus生殖能力的观察结果。对未经治疗和化疗的患者切除盘尾丝虫病体以及长期病媒控制地区居民中酶分离的成虫进行了调查,以评估其繁殖能力。在使用干扰子宫内发育的微丝药物治疗后,评估或估计子宫内微丝发育和微丝释放的变化。子宫内微丝的产生:经伊维菌素治疗后,观察到每只雌虫每天可产生2500至4000个子宫微丝。微丝虫实际产出:微丝虫主动离开雌虫。经甲苯达唑治疗后,每日体内微丝蚴释放量为700 ~ 900个。在体外,从未经治疗的患者中分离出的大多数蠕虫每天脱落500至1500个微丝虫。- 56例成人患者皮肤微丝蚴计数计算的微丝蚴载量平均为1200万个。假定微丝虫的平均寿命为1.0至1.5年,每位患者22至47只雌虫就足以将微丝虫负荷维持在恒定水平。切除所有可触及的结节显示,这些患者的几何平均为15.9雌性蠕虫。提示寄主和成虫体内的内在因子部分共同作用,调节和维持微丝虫密度的稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Tick-borne encephalitis in Europe. Serologic evidence for tick-borne encephalitis (TBE) in North-American military stationed in Germany. A small yaws survey on the island of Sumatra, Indonesia. Ultrastructural changes in the blood-brain barrier of mice infected with Plasmodium berghei. Onchocerca Volvulus infection in Sierra Leone: relation between prevalence, intensity of infection, and ocular problems in a 'forest' region.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1