Ooid and Aligned-Intranodal Palisaded Myofibroblastoma

Abstract

Intranodal palisaded myofbroblastoma is an uncommon, benign neoplasm arising within lymph nodes and commonly incriminates inguinal lymph nodes. Of obscure pathogenesis, intranodal palisaded myofibrobastoma may concur with overexpression of cyclin D1 or viral oncogenesis and manifests as a painless, gradually progressive tumefaction. Pathognomonic morphological features appear as proliferation of spindle shaped cells with nuclear palisading, a collagenous pseudo-capsule and compressed circumscribing peripheral lymph node tissue. Also, amianthoid fibres delineating fine, peripheral spokes, focal pauci-cellular zones and extracellular or intracellular fuchsinophilic bodies may be discerned.