Padua prediction score-guided use of low-molecular-weight heparin calcium treatment for the prevention of venous thromboembolism in elderly patients with intracerebral hemorrhage: a clinical observation

IF 1 4区 医学 Q3 EMERGENCY MEDICINE Signa Vitae Pub Date : 2023-01-01 DOI:10.22514/sv.2023.091
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Abstract

This study used the Padua Prediction Score (PPS) to guide low-molecular-weight heparin calcium (LMWHC) treatment for the prevention of venous thromboembolism (VTE) in elderly patients with intracerebral hemorrhage (ICH). This study retrospectively analyzed 225 elderly patients who were admitted to the intensive care unit (ICU) between June 2016 and June 2022. Patients were divided into control (n = 124) and study (n = 101) groups. Control patients received routine prevention and treatment of VTE, while patients in the study group received PPS-guided LMWHC treatment for the prevention of VTE. Multiple analytical parameters were assessed including thromboelastography indices, coagulation function parameters, venous blood flow velocity, and the incidence of VTE and recurrent ICH. Thromboelastography indices, coagulation function parameters, and the venous blood flow velocity did not differ significantly between the control and study groups (p > 0.05) before intervention and treatment. However, following PPS-guided LMWHC treatment, a significant improvement in these parameters was observed in the study group compared to the control group (p < 0.05). Furthermore, the incidence of VTE was significantly lower in the study group (5.6%) than the control group (14.5%; p = 0.038). No significance differences in the incidence of recurrent ICH were observed (p > 0.05). Our PPS data indicate that LMWHC treatment could significantly improve the coagulation function of elderly patients with ICH, as well as increase the venous blood flow velocity and prevent the occurrence of VTE.
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Padua预测评分指导下应用低分子肝素钙治疗预防老年脑出血患者静脉血栓栓塞的临床观察
本研究采用帕多瓦预测评分(PPS)指导低分子肝素钙(LMWHC)治疗预防老年脑出血(ICH)患者静脉血栓栓塞(VTE)。本研究回顾性分析了2016年6月至2022年6月期间入住重症监护病房(ICU)的225例老年患者。患者分为对照组(n = 124)和研究组(n = 101)。对照组患者采用常规预防和治疗VTE,研究组患者采用pps引导下的LMWHC治疗预防VTE。评估多项分析参数,包括血栓弹性成像指数、凝血功能参数、静脉血流速、静脉血栓栓塞发生率和复发性脑出血。血栓弹性成像指标、凝血功能参数和静脉血流速在对照组和研究组之间无显著差异(p >0.05)。然而,在pps引导下的LMWHC治疗后,与对照组相比,研究组在这些参数上有显着改善(p <0.05)。研究组静脉血栓栓塞发生率(5.6%)明显低于对照组(14.5%,p = 0.038)。两组脑出血复发的发生率无显著性差异(p >0.05)。我们的PPS数据表明,LMWHC治疗可以显著改善老年脑出血患者凝血功能,提高静脉血流速度,预防静脉血栓栓塞的发生。
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来源期刊
Signa Vitae
Signa Vitae 医学-急救医学
CiteScore
1.30
自引率
9.10%
发文量
0
审稿时长
3 months
期刊介绍: Signa Vitae is a completely open-access,peer-reviewed journal dedicate to deliver the leading edge research in anaesthesia, intensive care and emergency medicine to publics. The journal’s intention is to be practice-oriented, so we focus on the clinical practice and fundamental understanding of adult, pediatric and neonatal intensive care, as well as anesthesia and emergency medicine. Although Signa Vitae is primarily a clinical journal, we welcome submissions of basic science papers if the authors can demonstrate their clinical relevance. The Signa Vitae journal encourages scientists and academicians all around the world to share their original writings in the form of original research, review, mini-review, systematic review, short communication, case report, letter to the editor, commentary, rapid report, news and views, as well as meeting report. Full texts of all published articles, can be downloaded for free from our web site.
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