Co-relationship between Helicobacter pylori infection and patient of phenotype RIPK3 and gastric carcinoma in AL-Diywaniah Province, Iraq

Abstract

Objective: To diagnose H. pylori infection and assess the likelihood of developing gastric cancer. It is necessary to describe instances and phenotypes of necroptosis in gastric cells. Methodology: Fifty patients who had undergone gastrectomy from January 2020 to December 2022 were interviewed. A noninvasive investigation has been performed on each specimen to check for the presence of H. pylori by using stool, antibody test, urea breath test, and biopsy taken on endoscopy. Results: Increased population of RIPK3-positive cells was observed in both gastric glands and lamina propria in H. pylori infected human oxyntic gastritis and atrophic specimens. Phenotypic analysis revealed that many RIPK3-positive cells were H + K+ ATPase-positive parietal cells in the gastric glands and are predominantly CD3-positive T lymphocytes CD68-positive macrophages, and SMA-alpha-positive stromal cells. Positive tests for H. pylori were conducted on 50 individuals on chemotherapy who already had gastric cancer as a consequence of exposure to bacteria. The incidence of stomach cancer was 62% in males and 38% in females with age between 30-85 years. Conclusion: An increased population of RIPK3-positive cells was observed in several types of gastric cells. Future studies that define the effects and mechanisms developed of H. pylori disorders are needed.