Plasma IL-33 levels and immune activation in HIV-TB coinfection: a cross-sectional study in Yaoundé, Cameroon

René Ghislain Essomba, Rostand Munkam Mbe, Marie Paule Ngongang, Claire Bitchong Ekono, Valentina Josiane Ngo, Nassif Seni, Philippe Salomon Nguwoh, Pulchérie Thérèse Ateba, Severin Donald Kamdem, Justin Komguep Nono, Myriam Sylvie Ambomo, Marie Claire Okomo, François Xavier Mbopi-Kéou
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Abstract

Introduction: HIV-1 and Mtb are characterized by immune activation and unbalances production of cytokines, but the expression of IL33 in HIV/TB coinfection remain understudied. This study aimed to evaluate the level of IL-33 in plasma of HIV and M.tuberculosis (HIV/TB) coinfected patients compared to patients with respective mono infections in Yaoundé.
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血浆IL-33水平和HIV-TB合并感染的免疫激活:喀麦隆yaound的横断面研究
HIV-1和Mtb的特征是免疫激活和细胞因子的不平衡产生,但IL33在HIV/TB合并感染中的表达仍未得到充分研究。本研究旨在评价云南省HIV和结核分枝杆菌(HIV/TB)合并感染患者血浆中IL-33的水平。
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