Biochemical pancreatic β-cell lineage reprogramming: Various cell fate shifts

IF 3.2 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Current Research in Translational Medicine Pub Date : 2023-09-21 DOI:10.1016/j.retram.2023.103412

Yuqin Wang , Zhuoqing Liu , Shengren Li , Xuejuan Su , Keng Po Lai , Rong Li

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Abstract

The incidence of pancreatic diseases has been continuously rising in recent years. Thus, research on pancreatic regeneration is becoming more popular. Chronic hyperglycemia is detrimental to pancreatic β-cells, leading to impairment of insulin secretion which is the main hallmark of pancreatic diseases. Obtaining plenty of functional pancreatic β-cells is the most crucial aspect when studying pancreatic biology and treating diabetes. According to the International Diabetes Federation, diabetes has become a global epidemic, with about 3 million people suffering from diabetes worldwide. Hyperglycemia can lead to many dangerous diseases, including amputation, blindness, neuropathy, stroke, and cardiovascular and kidney diseases. Insulin is widely used in the treatment of diabetes; however, innovative approaches are needed in the academic and preclinical stages. A new approach aims at synthesizing patient-specific functional pancreatic β-cells. The present article focuses on how cells from different tissues can be transformed into pancreatic β-cells.

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生化胰腺β细胞系重编程：各种细胞命运转变

近年来，胰腺疾病的发病率持续上升。因此，有关胰腺再生的研究越来越受欢迎。长期高血糖会损害胰腺β细胞，导致胰岛素分泌障碍，这是胰腺疾病的主要特征。获得大量功能性胰腺β细胞是研究胰腺生物学和治疗糖尿病的最关键环节。据国际糖尿病联合会称，糖尿病已成为一种全球性流行病，全球约有 300 万人患有糖尿病。高血糖可导致多种危险疾病，包括截肢、失明、神经病变、中风以及心血管和肾脏疾病。胰岛素被广泛用于治疗糖尿病，但在学术和临床前阶段需要创新方法。一种新方法旨在合成患者特异的功能性胰岛β细胞。本文重点探讨如何将不同组织的细胞转化为胰腺β细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Research in Translational Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

7.00

自引率

4.90%

发文量

审稿时长

45 days

期刊介绍： Current Research in Translational Medicine is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of hematology, immunology, infectiology, hematopoietic cell transplantation, and cellular and gene therapy. The journal considers for publication English-language editorials, original articles, reviews, and short reports including case-reports. Contributions are intended to draw attention to experimental medicine and translational research. Current Research in Translational Medicine periodically publishes thematic issues and is indexed in all major international databases (2017 Impact Factor is 1.9). Core areas covered in Current Research in Translational Medicine are: Hematology, Immunology, Infectiology, Hematopoietic, Cell Transplantation, Cellular and Gene Therapy.