Assessment of Biochemical Parameters of Graft Survivors Post Renal Transplantation at King Faisal Hospital in Rwanda

Edgard Sumbiri, Cedrick Izere, Thierry Habyarimana, Callixte Yadufashije, Francois N. Niyonzima
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Abstract

Background: Chronic kidney disease (CKD) remains a public health concern of 21st century. Each year, over million people die from CKD resulting from the lack of proper diagnosis and treatment of this terrible disease of the urinary system. Non-communicable diseases (NCDs) cause roughly 60% of all deaths worldwide. There is insufficient data in Rwanda for the management of kidney diseases and other NCDs for all health facilities. Renal substitution therapy appears to be the best solution for long–suffering patients with end-stage renal illness who want to survive. The study’s purpose was to find out the serum creatinine and blood urea nitrogen (BUN) concentrations among kidney transplanted patients at King Faisal Hospital of Rwanda, and to show the consequences linked with the transplantation of kidney. Methods: This was a retrospective study carried from November 2018 to December 2019. The data were collected from medical records at King Faisal Referral Hospital, and analysed with SPSS version 22. Results: BUN and serum creatinine concentrations ranged from 77.4 to 93.5% and 67.8 to 87.1%, respectively. BUN levels that were abnormally high ranged from 3.2 to 19.4%, while creatinine levels that were abnormally high ranged from 6.5 to 29.0%. BUN and creatinine levels that were abnormally low, ranged from 0.0 to 6.5 and 3.2 to 9.7%, respectively. Diabetes mellitus affected 19.35% of the study population, hypertension affected 35.48%, and antibodymediated rejection affected 6.45%. Conclusion: The slight change in biochemical parameters may be a problem after kidney transplantation. There should be a monitoring of biochemical parameters tests to prevent the post kidney transplantation complications.
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卢旺达费萨尔国王医院肾移植术后移植幸存者的生化指标评估
背景:慢性肾脏疾病(CKD)仍然是21世纪的公共卫生问题。由于缺乏对这种可怕的泌尿系统疾病的适当诊断和治疗,每年有超过一百万人死于慢性肾病。非传染性疾病(NCDs)造成的死亡约占全球死亡总数的60%。卢旺达所有卫生设施管理肾脏疾病和其他非传染性疾病的数据不足。肾脏替代疗法似乎是长期痛苦的终末期肾病患者想要生存的最佳解决方案。该研究的目的是查明卢旺达费萨尔国王医院肾移植患者的血清肌酐和血尿素氮(BUN)浓度,并显示与肾移植有关的后果。方法:回顾性研究于2018年11月至2019年12月进行。数据是从费萨尔国王转诊医院的医疗记录中收集的,并使用SPSS 22版进行分析。结果:BUN和血清肌酐浓度分别为77.4 ~ 93.5%和67.8 ~ 87.1%。BUN异常高的范围为3.2 ~ 19.4%,肌酐异常高的范围为6.5 ~ 29.0%。BUN和肌酐水平异常低,分别在0.0 ~ 6.5%和3.2 ~ 9.7%之间。糖尿病占研究人群的19.35%,高血压占35.48%,抗体介导的排斥反应占6.45%。结论:肾移植术后生化指标的轻微变化可能是一个问题。应监测肾移植后的生化指标,以预防肾移植后并发症的发生。
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