[Fc-receptor mediated immune complex clearance function of the mononuclear phagocyte system in systemic lupus erythematosus].

Allergie und Immunologie Pub Date : 1990-01-01
P Kästner, H Franke, P Kleinert, C Günther, K Malberg, M Löbnitz
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引用次数: 0

Abstract

Fc receptor mediated immune complex clearance function was measured in patients with systemic lupus erythematosus. Autologous erythrocytes were sensitized by human IgG anti-Rh(D) and used as immune complex model. An impaired Fc receptor function was demonstrable in 20 of 25 investigated patients. We have found a significant correlation between the seriousness of the defect and the step of the immunologic activity of the patients, but not between the impaired Fc receptor function and clinical activity and renal manifestation in our SLE patients. Further studies are necessary to determine the relevance of this phenomenon and to clear the possibility of therapeutical influence.

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系统性红斑狼疮单核吞噬细胞系统fc受体介导的免疫复合物清除功能。
研究了系统性红斑狼疮患者Fc受体介导的免疫复合物清除功能。采用人IgG抗rh (D)致敏的自体红细胞作为免疫复合物模型。在25名被调查的患者中,有20名患者的Fc受体功能受损。在我们的SLE患者中,我们发现缺陷的严重程度与患者免疫活动的阶段有显著的相关性,而Fc受体功能受损与临床活动和肾脏表现之间没有显著的相关性。需要进一步的研究来确定这一现象的相关性,并明确治疗影响的可能性。
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