In vivo Investigation to Validate the Traditional Usage of Sorbaria tomentosa (Lindley) Reh. Root Extract against Alloxan-induced Diabetic Rats

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-11-08 DOI:10.5530/pres.15.4.071
Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani
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Abstract

Pharmacognosy Research,2023,15,4,671-678.DOI:10.5530/pres.15.4.071Published:October 2023Type:Original ArticleAuthors:Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, and Sushila Rani Author(s) affiliations:Monika Mehta*, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani Department of Botany, Panjab University, Chandigarh, INDIA. Abstract:Background: DM is a complicated condition that impacts the handling of sugar, fat, and protein metabolism in our bodies. Medicinal herbs play a significant role in diabetes care. As a result, we focused on the plant components traditionally employed by regional medical professionals. Objectives: The current research was carried out to check if Sorbaria tomentosa (Lindley) Reh. (ST) the ethanolic root extracts anti-diabetic potential. ST is a member of the Rosaceae family commonly known by the common name "false spirae." The root extract of ST is used by the locals in the Kinnaur district of Himachal Pradesh to effectively treat diabetes. Materials and Methods: Plant ethanolic extracts were evaluated for their potential on alloxan-induced diabetic rats for 14 days. The animals were put into one of four treatment groups at random: a normal control group, not treated diabetic control group (150 mg/kg bw), a drug control group that got glibenclamide (5 mg/kg bw), and the last treatment group medicated with ST root extract (50 mg/kg BW). Liver, pancreas, and kidney histopathology were analyzed to correlate biochemical findings with histological changes. Results: Our results showed that the extract and medication-treated diabetic groups gained statistically significant weight (p≤0.001) and that their BGL went back to normal. Along with more common biological markers such as SGOT, SGPT, ALP, TC, TG, HDL, LDL, VLDL, creatinine level, uric acid, urea, and uric acid were measured. After the extract treated hyperglycaemic rats, all biochemical markers came under the normal range (p≤0.001). Improvement of the damaged structure of the liver, pancreas, and kidneys was observed after treatment with standard medication and root extracts of ST. Conclusion: Based on the data gathered from the tribal research area, to the best of our capacity, we have uncovered for the very first time the anti-diabetic efficacy of the plant parts. The empirical knowledge of previous generations is typically the basis for the traditional utilization of medicinal plants for controlling diabetes. Nevertheless, in vivo, research has assisted to discover the anti-diabetic potential of ST's ethanolic root extract and provides scientific proof to back up these claims. The plant component may also be used to create natural antidiabetic drugs that are effective. Keywords:Alloxan, Diabetes mellitus, Kinnaur, Sorbaria tomentosa, Traditional knowledge, Wistar ratsView:PDF (1.41 MB)
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毛毡Sorbaria tomentosa (Lindley) Reh.)传统用法的体内研究。根提取物抗四氧嘧啶诱导的糖尿病大鼠
出版日期:2023年10月类型:原创作者:Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani作者单位:Monika Mehta*, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani印度旁遮普大学植物学系,昌迪加尔摘要:背景:糖尿病是一种影响体内糖、脂肪和蛋白质代谢的复杂疾病。草药在糖尿病治疗中起着重要的作用。因此,我们将重点放在传统上由区域医疗专业人员使用的植物成分上。目的:本研究旨在探讨毛囊Sorbaria tomentosa (Lindley) Reh。(ST)乙醇根提取物的抗糖尿病潜能。ST是蔷薇科的一员,通常被称为“假螺旋”。喜马偕尔邦金纳尔地区的当地人使用ST的根提取物来有效治疗糖尿病。材料与方法:观察植物乙醇提取物对四氧嘧啶诱导的糖尿病大鼠的作用。随机分为正常对照组、未治疗糖尿病对照组(150 mg/kg bw)、格列本脲药物对照组(5 mg/kg bw)和ST根提取物(50 mg/kg bw) 4个治疗组。分析肝脏、胰腺和肾脏的组织病理学,将生化结果与组织学变化联系起来。结果:我们的研究结果显示,提取物组和药物治疗组的体重增加有统计学意义(p≤0.001),BGL恢复正常。同时测量SGOT、SGPT、ALP、TC、TG、HDL、LDL、VLDL、肌酐水平、尿酸、尿素和尿酸等更常见的生物标志物。提取物对高血糖大鼠处理后,各项生化指标均在正常范围内(p≤0.001)。用标准药物和ST.根提取物治疗后,观察到肝脏、胰腺和肾脏受损结构的改善。结论:根据从部落研究地区收集的数据,我们尽最大努力,首次发现了植物部分的抗糖尿病功效。前几代人的经验知识通常是传统利用药用植物控制糖尿病的基础。然而,在体内,研究已经帮助发现了ST的乙醇根提取物的抗糖尿病潜力,并提供了科学证据来支持这些说法。植物成分也可用于制造有效的天然抗糖尿病药物。关键词:四氧嘧啶,糖尿病,金牛,毛囊索巴利亚,传统知识,Wistar大鼠
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来源期刊
Pharmacognosy Research
Pharmacognosy Research PHARMACOLOGY & PHARMACY-
自引率
14.30%
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61
期刊介绍: Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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