In vitro Urolithiasis Activity of Tridax procumbens Methanolic Extract on Calcium Oxalate Crystals Prepared by Precipitation Method

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-11-08 DOI:10.5530/pres.15.4.070

Aithamraju Satishchandra, Alagarsamy V Alagarsamy, Radhika V Radhika, V Ravi Kumar, Bandi Narendhar, P Subhash Chandra Bose

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Abstract

Pharmacognosy Research,2023,15,4,667-670.DOI:10.5530/pres.15.4.070Published:October 2023Type:Original ArticleAuthors:Aithamraju Satishchandra, V. Alagarsamy, V. Radhika, V Ravi Kumar, Bandi Narendhar, and P. Subhash Chandra Bose Author(s) affiliations:Aithamraju Satishchandra1,*, V. Alagarsamy2, V. Radhika2, V Ravi Kumar1, Bandi Narendhar2, P. Subhash Chandra Bose3 1Department of Pharmacology, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. 2Department of Pharmaceutical Chemistry, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. 3Department of Pharmaceutics, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. Abstract:Background: The main purpose of present to reduce the kidney stone with herbal drugs due increase in incidence rate of kidney stones significantly with change in life style from the last two decades. Aim and Methodology: The present study aimed to evaluate in vitro urolithiasis activity of Tridax procumbens on experimentally prepared calicium oxalate crystals. Calcium oxalate crystals were prepared by homogenous ppt method by using calium chloride and sodium oxalate. The crude extract was prepared by the simple maceration with methanol 1:3 ratio and the solvent was evaporated by rotary evaporator and two doses of extract selected i.e 10mg and 20 mg and compared against standard cytosine all were assayed against calcium oxalate crystals which were incubated in semi-permeable membrane with sulphuric acid. Results and Conclusion: The results were 68.02% (10 mg), 72.41% (20 mg) and 90% and we conclude that the Tridax procumbens was showed significant effect of urolithiasis. Keywords:Calcium oxalate crystals, Cytosine, PPT, Tridax procumbensView:PDF (197.05 KB)

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原杜仲甲醇提取物对沉淀法制备的草酸钙晶体的体外尿石活性研究

出版日期:2023年10月类型:原创文章作者:Aithamraju Satishchandra, V. Alagarsamy, V. Radhika, V Ravi Kumar, Bandi narendra har, P. Subhash Chandra Bose作者单位:Aithamraju Satishchandra1，*， V. Alagarsamy2, V. Radhika2, V Ravi Kumar1, Bandi narendra dhar2, P. Subhash Chandra Bose3印度，Telangana, Fasalwadi, Sangareddy, MNR药学院药学系。2印度特伦甘纳邦药学学院药物化学系，法萨尔瓦迪，Sangareddy，印度3印度特伦加纳邦Sangareddy法萨尔瓦迪MNR药学院药剂学系摘要:背景:本研究的主要目的是探讨近二十年来肾结石发病率随着生活方式的改变而显著增加的中药治疗肾结石的疗效。目的与方法:研究原甘菊对草酸钙晶体的体外抑石作用。以氯化钙和草酸钠为原料，采用均相ppt法制备了草酸钙晶体。粗提物以甲醇1:3的比例简单浸渍制得，溶剂经旋转蒸发器蒸发，选择10mg和20mg两种剂量的提物与标准胞嘧啶进行比较，并与草酸钙晶体在硫酸半透膜中孵育进行测定。结果与结论:结果分别为68.02% (10 mg)、72.41% (20 mg)和90%，说明原豆三通对尿石症有显著的治疗作用。关键词:草酸钙晶体，胞嘧啶，PPT，三甘菊

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Pharmacognosy Research PHARMACOLOGY & PHARMACY-

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期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.