{"title":"Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis","authors":"Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani Shivani S, Vikas Kumar Pal","doi":"10.5530/pres.15.4.088","DOIUrl":null,"url":null,"abstract":"Pharmacognosy Research,2023,15,4,831-840.DOI:10.5530/pres.15.4.088Published:October 2023Type:Original ArticleAuthors:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, and Vikas Kumar Pal Author(s) affiliations:Arun Kumar, Saurabh Singh*, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA. Abstract:Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments. Keywords:Azadirachta indica, Curcuma longa, haCaT cells, Pongamia pinnata, Psoralea corylifolia, Woodfordia fruticosaView:PDF (349.84 KB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 8","pages":"0"},"PeriodicalIF":0.7000,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacognosy Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/pres.15.4.088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Pharmacognosy Research,2023,15,4,831-840.DOI:10.5530/pres.15.4.088Published:October 2023Type:Original ArticleAuthors:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, and Vikas Kumar Pal Author(s) affiliations:Arun Kumar, Saurabh Singh*, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA. Abstract:Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments. Keywords:Azadirachta indica, Curcuma longa, haCaT cells, Pongamia pinnata, Psoralea corylifolia, Woodfordia fruticosaView:PDF (349.84 KB)
期刊介绍:
Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.