Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-11-08 DOI:10.5530/pres.15.4.086

Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, Saddala Rajeswara Reddy

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Pharmacognosy Research,2023,15,4,813-818.DOI:10.5530/pres.15.4.086Published:October 2023Type:Original ArticleAuthors:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, and Saddala Rajeswara Reddy Author(s) affiliations:Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. Abstract:Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future. Keywords:Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensisView:PDF (1.78 MB)

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补充tirupatiensis结核根对链脲佐菌素诱导的糖尿病大鼠氧化应激和肾毒性的减弱

《生药学研究》，2023,15,4,813-818.DOI:10.5530/pres.15.4.086出版日期:2023年10月类型:原创文章作者:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy和Saddala Rajeswara Reddy作者:Thopireddy lavany1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4，* 1印度KVR政府女子学院(A)， Cluster University, Kurnool, Andhra Pradesh, INDIA。2印度安得拉邦政府学位学院动物学系，普拉达尔;3 S.V.大学动物学系，印度安得拉邦蒂鲁帕蒂4德拉威大学草药研究与自然科学学院生物技术系民族药理学学部，印度安得拉邦库邦。摘要/ Abstract摘要:背景:印度东高止山脉Seshachalam山特有植物Pimpinella tirupatiensis (Pt)。目的:探讨其对链脲佐菌素(STZ)诱导的糖尿病大鼠肾脏氧化损伤的保护作用。材料和方法:用链脲佐菌素(40 mg kg-1 b.w)诱导糖尿病后，PTAq, Pt的水提取物以750 mg kg-1 b.w d -1的剂量口服。结果:糖尿病大鼠谷胱甘肽(GSH)、抗坏血酸和维生素E含量显著降低(p<0.01)，脂质过氧化(如MDA)、尿酸含量和黄嘌呤氧化酶(XOD)活性显著升高(p<0.01)。然而，糖尿病组添加PTAq可显著(p<0.01)提高谷胱甘肽(GSH)、抗坏血酸(AA)和维生素E含量，降低丙二醛(MDA)含量、尿酸含量和XOD活性。结论:本研究结果提示铂有可能避免实验性糖尿病大鼠氧化应激引起的糖尿病并发症，并可能在未来的糖尿病治疗中具有治疗意义。关键词:抗坏血酸，谷胱甘肽，脂质过氧化，非酶抗氧化剂，tirupatiensis

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Pharmacognosy Research PHARMACOLOGY & PHARMACY-

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期刊介绍： Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.