Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats
{"title":"Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats","authors":"Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, Saddala Rajeswara Reddy","doi":"10.5530/pres.15.4.086","DOIUrl":null,"url":null,"abstract":"Pharmacognosy Research,2023,15,4,813-818.DOI:10.5530/pres.15.4.086Published:October 2023Type:Original ArticleAuthors:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, and Saddala Rajeswara Reddy Author(s) affiliations:Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. Abstract:Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future. Keywords:Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensisView:PDF (1.78 MB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 11","pages":"0"},"PeriodicalIF":0.7000,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacognosy Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5530/pres.15.4.086","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
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Abstract
Pharmacognosy Research,2023,15,4,813-818.DOI:10.5530/pres.15.4.086Published:October 2023Type:Original ArticleAuthors:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, and Saddala Rajeswara Reddy Author(s) affiliations:Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. Abstract:Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future. Keywords:Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensisView:PDF (1.78 MB)
期刊介绍:
Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.