Crassocephalum crepidioides (Asteraceae) Benth S. Moore Leaves Fractions Attenuate Dyslipidemia and Atherogenic Indices in Diabetic Rats

IF 0.7 Q4 PHARMACOLOGY & PHARMACY Pharmacognosy Research Pub Date : 2023-11-08 DOI:10.5530/pres.15.4.080
Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, Omolaja Osoniyi
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Abstract

Pharmacognosy Research,2023,15,4,761-770.DOI:10.5530/pres.15.4.080Published:October 2023Type:Original ArticleAuthors:Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, and Omolaja Osoniyi Author(s) affiliations:Opeyemi Oluwayemisi Ayodele1,2,*, Funmilayo Dorcas Onajobi2, Emeka Emea Okoro1, Omolaja Osoniyi2,3 1Department of Biochemistry, College of Basic and Applied Sciences, Mountain Top University, Prayer, Ogun, NIGERIA. 2Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ilishan-Remo, Ogun, NIGERIA. 3Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun, NIGERIA. Abstract:Background: Diabetes mellitus, a metabolic and endocrine disorder, is associated with an impaired lipid profile that can result in increased atherogenic indices. The effects of the aqueous and hexane fractions of C. crepidioides leaves on the lipid profile and atherogenic indices of diabetic rats were investigated in this study. Materials and Methods: Varied concentrations (50-200 mg/kg body weight) of the aqueous (CAF) and hexane (CHF) fractions of C. crepidioides were assayed against streptozotocin-induced diabetic rats. Histological examinations of the pancreas were carried out using hematoxylin and eosin staining procedures. Experimental rats were randomly divided into 9 groups of 6 rats each and orally treated for 14 days. Results: The tested concentrations (50, 100 and 200 mg/kg) of CAF and CHF significantly (p < 0.05) reduced plasma glucose (51.3-62.2%), plasma and liver triglycerides (up to 50.5% in plasma; 66.1% in the liver), total cholesterol (up to 49.0% in plasma; 35.3% in the liver), low-density lipoprotein-cholesterol (up to 96.0 and 91.0% in the plasma and liver), very low-density lipoprotein-cholesterol (up to 50.5% in plasma; 55.0% in the liver), and the atherogenic indices elevated by diabetes induction. The high-density lipoprotein-cholesterol concentrations were significantly increased (plasma: 73.60-127.60%; liver: 108.70-152.5%) in CAF and CHF-treated diabetic rats compared to the diabetic control. Histological examination showed improved tissue architecture in the pancreas of the diabetic-treated rats compared to the diabetic control. Conclusion: C. crepidioides leaf fractions possess hypolipidemic and anti-atherogenic activities. Therefore, the plant could be useful in managing diabetes, dyslipidemia, and cardiovascular conditions. Keywords:Atherogenic indices, Diabetes mellitus, Dyslipidemia, Histological, Solvent fractionsView:PDF (619.52 KB)
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山菖蒲叶提取物对糖尿病大鼠血脂异常及动脉粥样硬化的影响
出版日期:2023年10月类型:原创文章作者:Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, Omolaja Osoniyi作者:Opeyemi Oluwayemisi ayodeli 1,2,*, Funmilayo Dorcas Onajobi2, Emeka Emea Okoro1, Omolaja Osoniyi 2,31尼日利亚奥冈市山顶大学基础与应用科学学院生物化学系。2基础医学院生物化学系,Benjamin S. Carson (Snr)巴布科克大学卫生与医学学院,尼日利亚奥贡伊利山-雷莫。3 Obafemi Awolowo大学生物化学与分子生物学教研室,尼日利亚奥松Ile-Ife摘要:背景:糖尿病是一种代谢和内分泌紊乱,与脂质谱受损相关,可导致动脉粥样硬化指数增加。本研究探讨了山参叶水馏分和己烷馏分对糖尿病大鼠血脂及动脉粥样硬化指标的影响。材料与方法:采用不同浓度(50 ~ 200 mg/kg体重)的水(CAF)和己烷(CHF)对链脲佐菌素诱导的糖尿病大鼠的作用进行了研究。采用苏木精和伊红染色方法对胰腺进行组织学检查。实验大鼠随机分为9组,每组6只,口服治疗14 d。结果:CAF和CHF浓度(50、100和200 mg/kg)显著(p < 0.05)降低血糖(51.3-62.2%)、血浆和肝脏甘油三酯(50.5%);66.1%在肝脏),总胆固醇(高达49.0%在血浆;低密度脂蛋白-胆固醇(在血浆和肝脏中分别高达96.0和91.0%),极低密度脂蛋白-胆固醇(在血浆中高达50.5%;肝脏55.0%),糖尿病诱导的动脉粥样硬化指数升高。高密度脂蛋白-胆固醇浓度显著升高(血浆:73.60-127.60%;与糖尿病对照组相比,CAF和chf治疗的糖尿病大鼠肝脏:108.70-152.5%)。组织学检查显示,与糖尿病对照组相比,糖尿病治疗大鼠胰腺的组织结构有所改善。结论:山参叶提取物具有降血脂和抗动脉粥样硬化作用。因此,这种植物可能对治疗糖尿病、血脂异常和心血管疾病有用。关键词:动脉粥样硬化指标,糖尿病,血脂异常,组织学,溶剂组分
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来源期刊
Pharmacognosy Research
Pharmacognosy Research PHARMACOLOGY & PHARMACY-
自引率
14.30%
发文量
61
期刊介绍: Pharmacognosy Research [ISSN: Print -0976-4836, Online - 0974-8490] [http://www.phcogres.com], Quarterly a publication of Phcog.Net is published by Wolters Kluwer - Medknow Publications. It provides peer-reviewed original research articles from the field of Natural Products. The journal serves an international audience of scientists and researchers in a variety of research and academia by quickly disseminating research findings related to Medicinal Plants and Natural Products. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submissions of original contributions in all areas of pharmacognosy are welcome.
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