Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated 3α,6α,7α,12α-Tetrahydroxylated Bile Acid in Cholestasis

IF 3.1 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Clinical and Translational Hepatology Pub Date : 2023-09-15 DOI:10.14218/jcth.2023.00095
Teng Liu, Ren-Xue Wang, Jun Han, Zhong-Die Li, Jonathan A. Sheps, Li-Juan Zheng, Xiao-Xiao Xu, Victor Ling, Jian-She Wang
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Abstract

Background and AimsWe asked if comprehensive bile acid profiling could provide insights into the physiopathology of ABCB4-mutated patients and evaluated the prognostic value of taurine-conjugated tetrahydroxylated bile acid (tauro-THBA) in cholestasis.
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abcb4突变患者的综合胆汁酸谱及牛磺酸偶联的3α,6α,7α,12α-四羟化胆汁酸在胆汁淤积症中的预后作用
背景和目的我们询问全面的胆汁酸谱分析是否可以为abcb4突变患者的生理病理提供见解,并评估牛磺酸偶联四羟基化胆汁酸(牛磺酸- thba)在胆汁淤积症中的预后价值。
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来源期刊
Journal of Clinical and Translational Hepatology
Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.40
自引率
2.80%
发文量
496
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