{"title":"The effect of cyclophosphamide on the Peyer's patches in MRL1/1 and NZB/WF1 mice.","authors":"H Yoshioka, T Sugiyama, T Kita","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>MRL1/1 & NZB/WF1 female mice were treated with high-dose cyclophosphamide (20 mg/kg/week), and the distribution of T cells in the Peyer's patches was examined in treated and untreated mice. A multiple layering technique was used for immunohistochemical detection of the lymphocyte surface antigens of T cells (Thy1.2, L3T4, Lyt2). High-dose cyclophosphamide inhibited the increase of the T cell population of MRL1/1 female mice with age, but little change was observed NZB/WF1 female mice.</p>","PeriodicalId":73745,"journal":{"name":"Journal of Experimental Pathology","volume":"5 1","pages":"19-27"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental Pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
MRL1/1 & NZB/WF1 female mice were treated with high-dose cyclophosphamide (20 mg/kg/week), and the distribution of T cells in the Peyer's patches was examined in treated and untreated mice. A multiple layering technique was used for immunohistochemical detection of the lymphocyte surface antigens of T cells (Thy1.2, L3T4, Lyt2). High-dose cyclophosphamide inhibited the increase of the T cell population of MRL1/1 female mice with age, but little change was observed NZB/WF1 female mice.
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