Synthesis and Biological Activity of Indeno-Pyridine and Indeno-Pyran Derivatives in One-Pot Reaction

Abstract

The peculiar one-pot reaction involving Carbaldehydes, malononitrile, and indane 1,3-dione was used to explain the alternative synthesis of indeno-pyridine and indeno-pyran derivatives. The synthesis of indeno-pyridine or indeno-pyran derivatives has been examined based on an effective modification in the Michael addition of indane 1,3-dione or malononitrile on Knoevenagel product throughout the reaction process. The reaction required up to 30 min to complete utilizing CuO nanoparticles (NPs) in water at room temperature, making the approach innovative and environmentally benign. All of the produced compounds have been validated using spectroscopic data. And they were then tested for their antimicrobial activities. All tested compounds showing greater efficacy against Sertaconazol and Chloramphenicol.