Fabrication of molecularly imprinted polymer‐based interdigital sensor for L‐ascorbic acid

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-11-07 DOI:10.1002/sia.7266

Muafia Akbar, Nauman Sadiq, Memoona Shakoor, Muhammad Shafique, Anum Tahir, Muhammad Zahid, Ghulam Mustafa

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Abstract

The level of L‐ascorbic acid (AA) in various natural and artificial foods, medicines and other substances must be determined for biological and agricultural purposes. In this study, an AA‐imprinted poly (methacrylic acid)‐based receptor was synthesized by thermal free‐radical bulk polymerization for the detection of ascorbic acid using the methacrylic acid as monomer, ethylene glycol dimethacrylate (EGDMA) as cross‐linker, and azobisisobutyronitrile (AIBN) as initiator, in the presence of a porogenic solvent dimethyl sulfoxide (DMSO). The synthesized molecularly imprinted polymer (MIP) was used as a receptor. Immobilization of the receptor layer on IDEs provided a suitable sensor for AA detection by measuring changes in electrical parameters including inductance, capacitance, and resistance with the help of LCR meter. In the series and parallel inductance, the lowest detection limits were 0.13 and 0.001 ppm, respectively. While, for series and parallel capacitance, the lowest detection limits were 0.01548 and 1.3698 ppm, respectively. In the case of resistance, the lowest limit of detection was 0.0076 and 0.08121 ppm in series and parallel, respectively. The imprinted polymer‐based sensor showed sensitivity, selectivity, and reversibility for ascorbic acid.

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L -抗坏血酸分子印迹聚合物数字间传感器的制备

L -抗坏血酸(AA)在各种天然和人工食品、药品和其他物质中的含量必须用于生物和农业目的。本研究以甲基丙烯酸为单体，乙二醇二甲基丙烯酸酯(EGDMA)为交联剂，偶氮二异丁腈(AIBN)为引发剂，在致孔溶剂二甲亚砜(DMSO)的存在下，采用热自由基本体聚合法制备了AA印迹聚甲基丙烯酸基受体，用于检测抗坏血酸。合成的分子印迹聚合物(MIP)作为受体。将受体层固定在IDEs上，通过LCR计测量电感、电容、电阻等电参数的变化，为AA检测提供了合适的传感器。在串联和并联电感中，最低检出限分别为0.13 ppm和0.001 ppm。串联电容和并联电容的最低检出限分别为0.01548 ppm和1.3698 ppm。在电阻情况下，串联和并联的最低检出限分别为0.0076和0.08121 ppm。印迹聚合物传感器对抗坏血酸具有灵敏度、选择性和可逆性。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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