{"title":"DIESL fuels a DGAT-independent triglyceride synthesis pathway","authors":"Lauren F Uchiyama, Peter Tontonoz","doi":"10.1093/lifemeta/load039","DOIUrl":null,"url":null,"abstract":"Alternative triglyceride (TG) synthesis pathways have yet to be identified in mammalian cells. In a recent article published in Nature, Brummelkamp and colleagues reported the acyltransferase TMEM68/DIESL synthesizes TG in the absence of the canonical enzymes diacylglycerol acyltransferase 1 (DGAT1) and DGAT2.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"22 1","pages":"0"},"PeriodicalIF":3.4000,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/lifemeta/load039","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Alternative triglyceride (TG) synthesis pathways have yet to be identified in mammalian cells. In a recent article published in Nature, Brummelkamp and colleagues reported the acyltransferase TMEM68/DIESL synthesizes TG in the absence of the canonical enzymes diacylglycerol acyltransferase 1 (DGAT1) and DGAT2.
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