Multiscale 3D bioprinting for the recapitulation of lung tissue

IF 6.8 3区 医学 Q1 ENGINEERING, BIOMEDICAL International Journal of Bioprinting Pub Date : 2023-09-04 DOI:10.36922/ijb.1166
Pengbei Fan, Fanli Jin, Yanqin Qin, Yuanyuan Wu, Qingzhen Yang, Han Liu, Jiansheng Li
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Abstract

Lung tissue engineering (LTE) has gained significant attention as a highly promising and innovative strategy to tackle the formidable obstacles posed by lung-related diseases and the lack of compatible donor organs availability. In the realm of groundbreaking advancements in tissue engineering (TE), one particular technology that has emerged as a game-changer is three-dimensional (3D) bioprinting. It distinguishes itself by offering a potent and versatile approach to constructing intricate structures while opening up new horizons for TE and regenerative medicine (RM). This review focuses on the application of multiscale 3D bioprinting techniques in LTE and the reconstitution of lung tissue in vitro. We analyzed the key aspects such as bioink formulations and printing strategies utilized from macroscale 3D bioprinting to micro/nanoscale 3D bioprinting. Additionally, we evaluated the potential of multiscale bioprinting to replicate the complex architecture of the lung, ranging from macrostructures to micro/nanoscale features. We discussed the challenges and future directions in biofabrication approaches for LTE. Furthermore, we highlight the current progress and future perspectives in tissue reconstitution of lung in vitro, considering factors such as cell source, functionalization, and integration of physiological cues. Overall, multiscale 3D bioprinting offers exciting possibilities for the development of functional lung tissues, enabling disease modeling, new drug screening, and personalized regenerative therapies.    
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用于肺组织再现的多尺度3D生物打印
肺组织工程(LTE)作为一种非常有前途和创新的策略,已经获得了极大的关注,以解决肺部相关疾病和缺乏相容供体器官所带来的巨大障碍。在组织工程(TE)领域的突破性进展中,一项特殊的技术已经成为改变游戏规则的技术,那就是三维(3D)生物打印。它的特点是提供了一种强大而通用的方法来构建复杂的结构,同时为TE和再生医学(RM)开辟了新的视野。本文综述了多尺度生物3D打印技术在LTE和体外肺组织重建中的应用。我们分析了从宏观生物3D打印到微/纳米尺度生物3D打印的关键方面,如生物墨水配方和打印策略。此外,我们评估了多尺度生物打印复制肺部复杂结构的潜力,从宏观结构到微/纳米尺度特征。我们讨论了LTE生物制造方法的挑战和未来方向。此外,我们强调了体外肺组织重建的当前进展和未来展望,考虑到细胞来源、功能和生理信号的整合等因素。总体而言,多尺度生物3D打印为功能性肺组织的开发提供了令人兴奋的可能性,使疾病建模、新药筛选和个性化再生治疗成为可能。,,,,
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来源期刊
CiteScore
6.90
自引率
4.80%
发文量
81
期刊介绍: The International Journal of Bioprinting is a globally recognized publication that focuses on the advancements, scientific discoveries, and practical implementations of Bioprinting. Bioprinting, in simple terms, involves the utilization of 3D printing technology and materials that contain living cells or biological components to fabricate tissues or other biotechnological products. Our journal encompasses interdisciplinary research that spans across technology, science, and clinical applications within the expansive realm of Bioprinting.
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