Laparoscopic Radical Cystectomy in a Low-Middle Income Country: A 5-Year Review of a Single Institution; Operative Data, Oncologic Results and Morbidity

Axel Stéphane Nwaha Makon, Landry Oriol Mbouche, Landry Tchuenkam, Laure Kamkui Dadje, Marcella Derboise Biyouma, Bertin Nginkeu Njinou, Pierre Joseph Fouda, Maurice Aurelien Sosso
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Abstract

Introduction and Objective: Laparoscopic radical cystectomy (LRC) is an alternative to open approach with lower morbidity and better oncologic outcome. We aim to share our experience on laparoscopic radical cystectomy and to evaluate our morbidity and oncological outcome in our settings. Methodology: An observational study in the Douala Medico-Surgical Urology Centre on 5 patients who underwent laparoscopic cystectomy with or without lymph node dissection and external urine diversion between April 2014 to July 2016 was conducted. The overall survival rate was subsequently estimated. Results: Four men and one woman underwent laparoscopic radical cystectomy during the 5-year study period with a mean age of 54.5-year-old. Three patients were submitted to ileal conduits, one to neobladders, and one patient to uretero-cutaneostomies. The mean operative time was 300 ± 17 minutes and the mean length of hospital stay was 9 ± 3 days. Three patients had minor complications according to Clavien and Dindon Classification treated conservatively without need for further operation. Four patients had transitional cell carcinoma and one Squamous cell carcinoma types. Everyone had negative resection margin while only two had negative lymph node. The median survival years in our study was 2.5 years, the overall survival rates at 2 years were 60%, 40% at 3 years and 20 at 5years. 2 patients die after one year due to renal failure and intercurrent disease. Conclusion: Laparoscopic radical cystectomy carried lower morbidity and cancerological outcome compare to open surgery making it a good alternative for bladder oncologic surgery.
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中低收入国家腹腔镜根治性膀胱切除术:单一机构的5年回顾手术资料、肿瘤结果和发病率
简介和目的:腹腔镜根治性膀胱切除术(LRC)是一种发病率较低、肿瘤预后较好的替代方法。我们的目的是分享我们在腹腔镜根治性膀胱切除术方面的经验,并评估我们的发病率和肿瘤预后。方法:对2014年4月至2016年7月在杜阿拉内科外科泌尿外科中心行腹腔镜膀胱切除术合并或不合并淋巴结清扫和外尿分流的5例患者进行观察性研究。随后估计总生存率。结果:在5年的研究期间,4名男性和1名女性接受了腹腔镜根治性膀胱切除术,平均年龄为54.5岁。3例患者行回肠导管,1例行新膀胱,1例行输尿管-皮肤造口术。平均手术时间300±17分钟,平均住院时间9±3天。根据Clavien和Dindon分类,3例患者出现轻微并发症,保守治疗,无需进一步手术。移行细胞癌4例,鳞状细胞癌1例。所有患者切除缘阴性,仅有2例淋巴结阴性。我们研究的中位生存年为2.5年,2年的总生存率为60%,3年为40%,5年为20%。2例患者在一年后因肾衰竭和并发疾病死亡。结论:腹腔镜根治性膀胱切除术与开放手术相比,发病率和肿瘤预后较低,是膀胱肿瘤手术的良好选择。
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