Ling-Tao Wang, Bo Zhou, Fa-Liang Liu, Wen-Ting Wei, Long-Wu Ye
{"title":"Radical strategies for chemodivergent cyclization reactions","authors":"Ling-Tao Wang, Bo Zhou, Fa-Liang Liu, Wen-Ting Wei, Long-Wu Ye","doi":"10.1016/j.trechm.2023.10.002","DOIUrl":null,"url":null,"abstract":"Chemodivergent reactions provide a unique platform for accessing expanded chemical space and diverse molecular structures from similar starting materials. The concept of tunable chemoselectivity can be realized by simple modifications to the substrate or reaction conditions. Among the known chemodivergent transformations, radical reactions have emerged as an exceedingly powerful toolbox for their simplicity and efficiency, creating a feasible path to achieve tunable chemoselectivity. This review focuses on recent progress since 2018 in controlling the different reaction pathways in radical cyclization reactions; substrate-dependent reactions, controlled by chain length, substituents and radical precursors, and condition-controlled reactions, mainly dominated by catalysts, bases, redox reagents, solvents, etc. Future avenues for investigation are also presented to help expand this exciting field.","PeriodicalId":48544,"journal":{"name":"Trends in Chemistry","volume":"27 11","pages":"0"},"PeriodicalIF":14.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.trechm.2023.10.002","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Chemodivergent reactions provide a unique platform for accessing expanded chemical space and diverse molecular structures from similar starting materials. The concept of tunable chemoselectivity can be realized by simple modifications to the substrate or reaction conditions. Among the known chemodivergent transformations, radical reactions have emerged as an exceedingly powerful toolbox for their simplicity and efficiency, creating a feasible path to achieve tunable chemoselectivity. This review focuses on recent progress since 2018 in controlling the different reaction pathways in radical cyclization reactions; substrate-dependent reactions, controlled by chain length, substituents and radical precursors, and condition-controlled reactions, mainly dominated by catalysts, bases, redox reagents, solvents, etc. Future avenues for investigation are also presented to help expand this exciting field.
期刊介绍：
Trends in Chemistry serves as a new global platform for discussing significant and transformative concepts across all areas of chemistry. It recognizes that breakthroughs in chemistry hold the key to addressing major global challenges. The journal offers readable, multidisciplinary articles, including reviews, opinions, and short pieces, designed to keep both students and leading scientists updated on pressing issues in the field.
Covering analytical, inorganic, organic, physical, and theoretical chemistry, the journal highlights major themes such as biochemistry, catalysis, environmental chemistry, materials, medicine, polymers, and supramolecular chemistry. It also welcomes articles on chemical education, health and safety, policy and public relations, and ethics and law.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
