Implications of Multimerin-1 (MMRN-1) expression in adult de novo acute myeloid leukemia: a preliminary study in Delta Egypt

Abstract

Adult acute myeloid leukemia (AML) is challengeable disease with poor heterogeneous outcome. Refining risk stratification is important for decision making and tailoring of therapy, multimerin-1(MMRN1) has been identified as a differentially expressed gene (DEG) in various cancers and it has been proposed as a possible cancer biomarker so, we aim to address prognostic value of Multimerin-1 in adult AML. This study was conducted on 240 AML, 40 healthy control, Taq man gene expression by RT PCR. Higher expression of Multimerin-1 was significant associated with failure of complete remission, relapse, short survival, highly significant association with minimal residual disease (MRD) positivity, molecular FLT3 (p 0.004, p.008) unfavorable cytogenetic (0.013). Cut off > 2.38 shows significantly short Overall Survival (OS), Disease-Free Survival (DFS). Finally, it could be independent poor risk for short survival; relapse thus may help in refine AML risk-stratification and tailoring therapy toward personalized medicine.