{"title":"A Potential Target for Treating Acute Myeloid Leukemia: XBP1 involved in Endoplasmic Reticulum Stress","authors":"neslihan abacı","doi":"10.5505/tjo.2023.3968","DOIUrl":null,"url":null,"abstract":"Endoplasmic reticulum (ER) stress, which occurs as a result of the accumulation of misfolded or un-folded proteins, has been observed in many cancers. To re-establish the ER homeostasis, pathways of un-folded protein response (UPR) are activated. The effect of ER stress-activated UPR pathways on leuke-mogenesis has not been elucidated. In this study, we aimed to find out whether activated UPR pathways were involved in acute myeloid leukemia (AML)","PeriodicalId":42117,"journal":{"name":"Turk Onkoloji Dergisi-Turkish Journal of Oncology","volume":"10 1","pages":"0"},"PeriodicalIF":0.3000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turk Onkoloji Dergisi-Turkish Journal of Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5505/tjo.2023.3968","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Endoplasmic reticulum (ER) stress, which occurs as a result of the accumulation of misfolded or un-folded proteins, has been observed in many cancers. To re-establish the ER homeostasis, pathways of un-folded protein response (UPR) are activated. The effect of ER stress-activated UPR pathways on leuke-mogenesis has not been elucidated. In this study, we aimed to find out whether activated UPR pathways were involved in acute myeloid leukemia (AML)
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