The Relationship Between the Number of Miscarriages and Diagnostic Parameters in Couples with Recurrent Pregnancy Loss: A Retrospective Cohort Study

Abstract

Objective: The aim of this study was to compare the ovarian reserve tests and abnormal test results in couples with 2 to more than 2 recurrent pregnancy losses in our population. Material and Methods: Seventy-five couples aged 20-44 years, who had two or more consecutive abortions at 20 weeks or less from the last menstrual period, were included in the study. The women were divided into two groups as those who had two miscarriages (Group 1, n=34) and those who had three or more miscarriages (Group 2, n=41). Women in both groups were compared in terms of serum hormone levels, biochemical parameters, karyotype analysis, thrombophilic, and uterine factors. The spermiogram values and karyotype analyzes of the male partners in both groups were compared. Results: The women in Group 2 were older than those in Group 1, and live birth history and Factor V Leiden heterozygosity were found to be statistically significantly higher. The follicle stimulating hormone values in the secondary recurrent pregnancy loss patients were found to be statistically significantly higher than in the primary recurrent pregnancy loss patients. Conclusion: Maternal age and Factor V Leiden heterozygosity may be associated with the number of miscarriages in couples with recurrent pregnancy loss.