Endotype Conformity with Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) Score in Chronic Rhinosinusitis

Abstract

Introduction: Chronic rhinosinusitis (CRS) is one of the most prevalent disease entities in ORL-HNS field. Management strategy of CRS remains challenging among otorhinolaryngologist. Currently, CRS was known as a heterogeneous disease with various endotypes and phenotypes. By identifying endotypes, comprehensive management strategy in CRS was expected. The Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis (JESREC) score was a categorical score developed from Japan to diagnose eosinophilic chronic rhinosinusitis (eCRS) and non-eosinophilic chronic rhinosinusitis (non-eCRS). The assessment of JESREC score was expected to have conformity with CRS endotypes so that it can be used as future efficient diagnostic modality. Objective: This study aims to determine conformity and accuracy of endotype with JESREC score. Patients and Methods: An analytic study with a cross-sectional design involving 33 samples of primary CRS. Biomarker for specific endotypes measured by ELISA. Results: Statistical analysis with Mc. Nemar showed no difference/ a conformity between JESREC score and CRS endotypes ( p>0.05 ) with sensitivity 61,5% and specificity 90%. Conclusion: JESREC score is considered a screening modality for CRS endotype.