A Study of Association of ABO and Rh Blood Group with Colorectal Cancer in Khuzestan Province, Iran

Hosein Jodat, Javad Jodat, Ali Khodadadi, Abdolhassan Talaiezadeh, Nazanin Joudaki, Ali Asadirad
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 Materials and Methods: We conducted a retrospective study involving 71 colorectal cancer patients diagnosed between 2018 and 2020 in Khuzestan province, Iran, with known ABO blood types. Large-scale data from 29,922 blood donors in Khuzestan served as the healthy population control. The study analyzed the distribution of ABO blood groups among the blood donors.
 Results: Our findings revealed that the distribution of blood groups among colorectal cancer patients was as follows: O (31.0%), A (29.6%), B (29.6%), and AB (9.8%). However, our analysis did not establish a significant association between colorectal cancer risk and ABO antigens (P-value = 0.636) or Rh blood group (P = 0.198). Additionally, no significant differences in ABO blood types were observed concerning gender (P = 0.802), cancer type (P = 0.338), or tumor type (P = 0.207) among colorectal cancer patients.
 Conclusion: This study does not support a significant correlation between ABO and Rh blood groups and the risk of colorectal cancer, nor does it find associations with cancer type or tumor type.","PeriodicalId":94048,"journal":{"name":"International journal of hematology-oncology and stem cell research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of hematology-oncology and stem cell research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijhoscr.v17i4.13919","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract

Background: Colorectal cancer, a solid tumor with a high prevalence, contributes significantly to annual mortality rates. Various factors, including blood groups, may influence cancer risk. Multiple studies have suggested a potential connection between ABO and Rh blood groups and colorectal cancer risk. This study aims to investigate the role of ABO and Rh blood groups as risk factors in colorectal cancer patients. Materials and Methods: We conducted a retrospective study involving 71 colorectal cancer patients diagnosed between 2018 and 2020 in Khuzestan province, Iran, with known ABO blood types. Large-scale data from 29,922 blood donors in Khuzestan served as the healthy population control. The study analyzed the distribution of ABO blood groups among the blood donors. Results: Our findings revealed that the distribution of blood groups among colorectal cancer patients was as follows: O (31.0%), A (29.6%), B (29.6%), and AB (9.8%). However, our analysis did not establish a significant association between colorectal cancer risk and ABO antigens (P-value = 0.636) or Rh blood group (P = 0.198). Additionally, no significant differences in ABO blood types were observed concerning gender (P = 0.802), cancer type (P = 0.338), or tumor type (P = 0.207) among colorectal cancer patients. Conclusion: This study does not support a significant correlation between ABO and Rh blood groups and the risk of colorectal cancer, nor does it find associations with cancer type or tumor type.
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伊朗胡齐斯坦省ABO和Rh血型与结直肠癌的相关性研究
背景:结直肠癌是一种高发病率的实体肿瘤,是造成年死亡率的重要因素。包括血型在内的各种因素都可能影响患癌症的风险。多项研究表明,ABO血型和Rh血型与结直肠癌风险之间存在潜在联系。本研究旨在探讨ABO血型和Rh血型在结直肠癌患者中的危险因素作用。材料和方法:我们对伊朗胡齐斯坦省2018年至2020年诊断的71例已知ABO血型的结直肠癌患者进行了回顾性研究。来自胡齐斯坦省29,922名献血者的大规模数据作为健康人口控制。本研究分析了献血者ABO血型的分布。 结果:结直肠癌患者的血型分布为:O型(31.0%)、A型(29.6%)、B型(29.6%)、AB型(9.8%)。然而,我们的分析并没有建立结直肠癌风险与ABO抗原(P值= 0.636)或Rh血型(P值= 0.198)之间的显著关联。此外,结直肠癌患者ABO血型在性别(P = 0.802)、癌症类型(P = 0.338)、肿瘤类型(P = 0.207)方面均无显著差异。 结论:本研究不支持ABO和Rh血型与结直肠癌风险有显著相关性,也未发现与癌症类型或肿瘤类型相关。
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