Macrophage Migration Inhibitory Factor and Gene Polymorphism (rs755622G>C) in Unstable Vitiligo Patients

IF 3.7 4区医学 Q1 DERMATOLOGY Dermatologic Therapy Pub Date : 2023-10-20 DOI:10.1155/2023/9937187

Hassan M. Ibrahim, Mohammed H. Hassan, Moustafa A. El-Taieb, Essam Nada, Soheir Abdel-Hamid, Ali Younis, Mahmoud Ali, Eisa M. Hegazy

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Abstract

Vitiligo pathogenesis is related to the macrophage migration inhibitory factor (MIF) protein. This study aimed to assess the lesional MIF levels and gene polymorphisms (rs755622G>C) in patients with vitiligo. To assess the consequences of combining narrow-band ultraviolet B with oral minipulse prednisolone as opposed to a combination with oral methotrexate on MIF levels in vitiligo patients, 50 unstable vitiligo patients and 50 controls were randomly chosen for comparison. MIF levels in skin homogenates and MIF (rs755622G>C) single nucleotide polymorphisms were assessed using the ELISA and the polymerase chain reaction restriction fragment length polymorphism (RFLP-PCR) techniques. We found significantly higher lesional MIF levels, a higher frequency of both (GC) and (CC) genotypes, and a significantly more frequent mutant allele (C) in patients than in controls. In addition, there was a significantly lower frequency of the allele (C) among patients who exhibited moderate to marked therapeutic improvement than among those who showed minimal to mild improvement. In conclusion, tissue MIF and gene polymorphisms were associated with vitiligo. In addition, oral corticosteroids, narrow-band ultraviolet B, methotrexate-targeted tissue MIF, and gene polymorphisms can improve unstable vitiligo.

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不稳定白癜风患者巨噬细胞迁移抑制因子与基因多态性(rs755622G>C

白癜风的发病机制与巨噬细胞迁移抑制因子(MIF)蛋白有关。本研究旨在评估白癜风患者的病变MIF水平和基因多态性(rs755622G>C)。为了评估窄带紫外线B联合口服微脉冲强的松龙与联合口服甲氨蝶呤对白癜风患者MIF水平的影响，随机选择50名不稳定型白癜风患者和50名对照组进行比较。使用ELISA和聚合酶链反应限制性片段长度多态性(RFLP-PCR)技术评估皮肤匀浆中的MIF水平和MIF (rs755622G>C)单核苷酸多态性。我们发现患者的病变MIF水平明显高于对照组，(GC)和(CC)基因型的频率更高，突变等位基因(C)的频率明显高于对照组。此外，在表现出中度至显著治疗改善的患者中，等位基因(C)的频率明显低于表现出轻微至轻度改善的患者。总之，组织MIF和基因多态性与白癜风有关。此外，口服皮质类固醇、窄带紫外线B、甲氨蝶呤靶向组织MIF和基因多态性可改善不稳定白癜风。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.